System of immunity in posttraumatic stress disorders

Abstract

90 male inpatients – participants of local combat actions on Caucasus with PTSD, aged 31,41 ± 0,88 years.

Analysis of structure of secondary immune deficiency (SID) in acute stress of combat actions has shown absence of SID in 31,7%, 68,3% - risk group for SID. Leading clinical syndrome - infectious (47,6%). More seldom allergic (3,7%) and autoimmune (2,4%) syndromes. 13,0% - combination of infectious and allergic syndromes.

In laboratory SID is confirmed in 37,5%. Study of the process of apoptosis has revealed a reliable as compared with control increase of content of CD95+ lymphocytes (p<0,001) in this group. It is possibly conditioned by formation of persistent ID with predominant decrease of Т-helpers/inductors, modifying apoptogenic signal and predominating the development of apoptosis during activation through receptor complex CD3+-TCR. In combatants as compared with control total number of phagocyting neutrophiles (p<0,001) and number of particles absorbed by one phagocyte (p<0,001) is decreased. Background activity of oxidant systems of neutrophiles compatible with indices of stimulated variant of HCT-test of healthy persons (p<0,05) is decreased. Humoral link of immunity is activated - increase of level of circulating immune complexes (p<0,001), increase of concentration of serum immunoglobulines of classes М (p<0,01), G (p<0,001) and А (p<0,05).

In the process of treatment, number of leukocytes, lymphocytes of HLA-DR+ phenotype, concentration of IgG, phagocytar activity of neutrophiles is restored to level of control. Number of lymphocytes of СD3+, CD4+- phenotypes remains decreased.