Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-27T19:59:42.393Z Has data issue: false hasContentIssue false
  • English
  • Français

Sustained and selective attention deficits as vulnerability markers to psychosis

Published online by Cambridge University Press:  16 April 2020

B. Mulet ,
J. Valero ,
A. Gutiérrez-Zotes ,
C. Montserrat ,
M.J. Cortés ,
M. Jariod ,
L. Martorell ,
E. Vilella  and
A. Labad
B. Mulet*
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain
J. Valero
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
A. Gutiérrez-Zotes
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
C. Montserrat
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain
M.J. Cortés
Affiliation:
Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
M. Jariod
Affiliation:
Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
L. Martorell
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain
E. Vilella
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
A. Labad
Affiliation:
Departament de Formació i Investigació, Hospital Psiquià tric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain Unitat de Psiquiatria i Psicologia Mèdica, Departament de Medicina i Cirurgia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Sant Llorenç, 21, 43201Reus, Spain
*
*Corresponding author. Tel.: +34 977 33 85 65x208; fax: +34 977 31 0021. E-mail address:[email protected] (B. Mulet).
Get access

Abstract

The first descriptions of schizophrenia emphasized attention problems patients with schizophrenia have but recent results evidence that other psychotic disorders share them.

We compared the performance in sustained and selective attention between psychotic patients (P), their healthy first degree relatives (R) and healthy volunteers (C) to prove whether these alterations could be an endophenotype of vulnerability to psychosis. We also compared the performance of schizophrenic patients (SZP) and that of patients with other functional psychoses (OP) in order to prove whether these alterations are specific of any psychotic disorder.

Seventy-six P, 70 R and 39 C were included in the study. A selective attention index, comprising TMT A and B and Stroop Test, and a sustained attention index comprising the Continuous Performance Test were calculated. We conducted an univariant general linear model to compare three group performances in these indexes, with age, sex and years of education as a covariables.

We found significant differences between the indexes when we compared P, R and C. No differences in performance were found between SZP and OP. Our data showed that sustained and selective attention alterations could be a vulnerability factor to psychotic disorders in general, but they were not specific of schizophrenia.

Keywords

AttentionCognitionEndophenotypeNeuropsychologyPsychosisVigilance
Type
Schizophrenia and Psychotic Disorder
Information
European Psychiatry , Volume 22 , Issue 3 , April 2007 , pp. 171 - 176
Copyright
Copyright © Elsevier Masson SAS 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beech, A.Powell, T.McWilliam, J.Claridge, G.Evidence of reduced ‘cognitive inhibition’ in schizophrenia. Br J Clin Psychol 1989;28:109–116.10.1111/j.2044-8260.1989.tb00821.xCrossRefGoogle Scholar
Bozikas, V.P.Andreou, C.Giannakou, M.Tonia, T.Anezoulaki, D.Karavatos, A.et al.Deficit in sustained attention in schizophrenia but not in bipolar disorder. Schizophr Res 2005;78(2–3):225–233.10.1016/j.schres.2005.05.014CrossRefGoogle ScholarPubMed
Conners, C.K.Conner's CPT-II. Continuous performance test II. Toronto: MHS; 2000.Google Scholar
Chan, M.C.Yip, J.T.H.Lee, T.M.C.Differential impairment on measures of attention in patients with paranoid and non-paranoid schizophrenia. J Psychiatr Res 2004;38:145–152.10.1016/S0022-3956(03)00102-XCrossRefGoogle Scholar
Chan, R.C.K.Chen, E.Y.H.Ceung, E.F.C.Chen, R.Y.L.Cheung, H.K.A study of sensitivity of the sustained attention to response task in patients with schizophrenia. Clin Neuropsychol 2004;18(1):114–121.10.1080/13854040490507208CrossRefGoogle ScholarPubMed
Chen, E.Y.H.Lam, L.C.W.Chen, R.Y.L.Nguyen, D.G.H.Chan, C.K.Y.Wilkins, A.J.Neuropsychological correlates of sustained attention in schizophrenia. Schizophr Res 1997;24:299–310.10.1016/S0920-9964(96)00120-XCrossRefGoogle Scholar
Chen, W.J.Faraone, S.V.Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Genet 2000;97:52–57.10.1002/(SICI)1096-8628(200021)97:1<52::AID-AJMG7>3.0.CO;2-63.0.CO;2-6>CrossRefGoogle Scholar
Cornblatt, B.A.Lezenweger, M.F.Erlenmeyer-Kimling, L.The Continuous Performance Test, Identical Pairs Version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 1989;29:65–85.10.1016/0165-1781(89)90188-1CrossRefGoogle Scholar
Egeland, J.Rund, B.R.Sundet, K.Landro, N.I.Asbjornsen, A.Lund, A.et al.Attention profile in schizophrenia compared with depression: differentials effects of processing speed, selective attention and vigilance. Acta Psychiatr Scand 2003;108:276–284.10.1034/j.1600-0447.2003.00146.xCrossRefGoogle Scholar
First, M.B.Gibbon, M.Spitzer, R.L.Williams, J.B.Benjamin, L.S.Entrevista clínica estructurada para los trastornos de la personalidad del Eje II del DSM-IV. SCID-II. Barcelona: Masson; 1999.Google Scholar
Golden, C.J.Stroop Test de palabras y colores. Madrid: TEA Ediciones; 1994.Google Scholar
Gruber, S.A.Rogowska, J.Holcom, P.Soraci, S.Yurgelun-Todd, D.Stroop performance in normal control subjects: an fMRI study. Neuroimage 2002;16(2):349–360.10.1006/nimg.2002.1089CrossRefGoogle Scholar
Hughes, C.Kumari, V.Das, M.Zachariah, E.Ettinger, U.Sumich, A.et al.Cognitive functioning in siblings discordant for schizophrenia. Acta Psychiatr Scand 2005;111:185–192.10.1111/j.1600-0447.2004.00392.xCrossRefGoogle Scholar
Jones, L.A.Cardno, A.G.Sanders, R.D.Owen, Williams, J.Sustained and selective attention as measures of genetic liability to schizophrenia. Schizophr Res 2001;48:263–272.10.1016/S0920-9964(00)00136-5CrossRefGoogle Scholar
Laplante, L.Everett, J.Thomas, J.Inhibition through negative priming with Stroop stimuli in schizophrenia. Br J Clin Psychol 1992;31:307–326.10.1111/j.2044-8260.1992.tb00998.xCrossRefGoogle Scholar
Lezak, M.Neuropsychological assessment. 3rd ed.New York: OUP; 1995.Google Scholar
Meyer, T.D.Blechert, J.Are attentional deficits in people putatively at risk for affective disorders? J Affect disorders 2005;84:63–72.10.1016/j.jad.2004.10.001CrossRefGoogle ScholarPubMed
Politis, A.Lykouras, L.Mourtzouchou, P.Christodoulou, G.N.Attentional disturbances in patients with unipolar psychotic depression: a selective and sustained attention study. Compr Psychiatry 2004;45:452–459.10.1016/j.comppsych.2004.07.007CrossRefGoogle ScholarPubMed
Salgado-Pineda, P.Junqué, C.Vendrell, P.Baeza, I.Bargalló, N.Falcón, C.et al.Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. Neuroimage 2004;21(3):840–847.10.1016/j.neuroimage.2003.10.027CrossRefGoogle ScholarPubMed
Schubert, E.W.McNeil, T.F.Neuropsychological impairment and its neurological correlates in adult offspring with heightened risk for schizophrenia and affective psychosis. Am J Psychiatry 2005;162(4):758–766.10.1176/appi.ajp.162.4.758CrossRefGoogle ScholarPubMed
Spreen, O.Strauss, E.A compendium of neuropsychological tests: administration, norms and commentary. New York: OUP; 1998.Google Scholar
Vázquez Barquero, J.L.SCAN: Cuestionarios para la Evaluación Clínica en Neuropsiquiatría. Adaptación al español. Madrid: Meditor; 1993.Google Scholar
Walker, E.Attentional and neuromotor functions of schizophrenic, schizoaffectives, and patients with other affective disorders. Arch Gen Psychiatry 1981;38:1355–1358.10.1001/archpsyc.1981.01780370057006CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.