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Subtyping of panic disorder patients with bradycardia

Published online by Cambridge University Press:  16 April 2020

J. Massana ,
J.A. López Risueño ,
G. Masana ,
T. Marcos ,
L. González  and
A. Otero
J.A. López Risueño
Affiliation:
Hospital Clínic i Provincial de Barcelona, Universitat de Barcelona, Villarroel 140, 08036Barcelona, Spain
G. Masana
Affiliation:
Hospital Clínic i Provincial de Barcelona, Universitat de Barcelona, Villarroel 140, 08036Barcelona, Spain
T. Marcos
Affiliation:
Hospital Clínic i Provincial de Barcelona, Universitat de Barcelona, Villarroel 140, 08036Barcelona, Spain
L. González
Affiliation:
Hospital Clínic i Provincial de Barcelona, Universitat de Barcelona, Villarroel 140, 08036Barcelona, Spain
A. Otero
Affiliation:
Hospital Clínic i Provincial de Barcelona, Universitat de Barcelona, Villarroel 140, 08036Barcelona, Spain
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Abstract

Purpose

Since clinical practice suggests that panic disorder may not be a homogeneous condition, a study was carried out to test the possible existence of different groups or subgroups of panic patients.

Subjects and methods

Thirty-two panic patients (DSM-III-R) underwent lactate challenge in our laboratory and were assessed for heart rate, blood pressure, sweating and Acute Panic Inventory.

Results

During the lactate challenge, patients complaining mainly of ‘cardiorespiratory’ symptoms (N = 12) showed tachycardia and localized sweating. Conversely, patients complaining mainly of ‘pseudoneurological’ symptoms (N = 16) showed bradycardia and generalized sweating. In both groups, Acute Panic Inventory scores were significantly higher during than before the panic attack, but the distribution of the scores was markedly different.

Discussion and Conclusion

The results suggest that panic disorder may be a heterogeneous condition. Implications of these results to other phobic disorders, to Klein’s false suffocation alarm theory and to the ‘extended amygdala model’ are discussed.

Keywords

bradycardiaextended amygdala modelfalse suffocation alarmmechanisms of panicpanic disordertachycardia
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 2 , March 2001 , pp. 109 - 114
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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