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Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo

Published online by Cambridge University Press:  16 April 2020

D Warot ,
E Corruble ,
C Payan ,
JS Weil  and
AJ Puech
D Warot
Affiliation:
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013Paris
E Corruble
Affiliation:
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013Paris
C Payan
Affiliation:
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013Paris
JS Weil
Affiliation:
Laboratoire Lafon, Centre de Recherche, 94701 Maisons Alfort Cedex, France
AJ Puech
Affiliation:
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013Paris
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Summary

The subjective, behavioral and physiological effects of modafinil (300 mg PO) a new central adrenergic stimulant, were compared with those of dextroamphetamine (15 mg PO), caffeine (300 mg PO) and placebo in a randomized double-blind cross-over study. Sixteen healthy volunteers participated in the study y: 8 males and 8 females with no history of drug abuse and moderate use of caffeine. Subjective and behavioral effects were studied using the Addiction Research Center Inventory (ARCI), Profile of Mood States (POMS) and Visual Analog Scales before and 1, 2, 4 and 8 h post single oral dosing. Results showed that subjective effects of modafinil (300 mg) differed markedly from those of dextroamphetamine (15 mg). They were close to those produced by caffeine (300 mg). These results indicate that modafinil (300 mg) does not possess amphetamine-like subjective effects in a healthy population. If subjective feelings are related to drug abuse liability, it could be assumed that modafinil, at the dose used in therapeutics, does not possess any abuse liability comparable to amphetamine.

Keywords

modafinilamphetaminecaffeinehealthy volunteersubjective effectsARCI
Type
Original article
Information
European Psychiatry , Volume 8 , Issue 4 , 1993 , pp. 201 - 208
Copyright
Copyright © Elsevier, Paris 1993

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