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The structure of the corpus callosum in obsessive compulsive disorder

Published online by Cambridge University Press:  15 April 2020

M. Di Paola ,
E. Luders ,
I.A. Rubino ,
A. Siracusano ,
G. Manfredi ,
P. Girardi ,
G. Martinotti ,
P.M. Thompson ,
Y.-Y. Chou  and
A.W. Toga
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M. Di Paola*
Affiliation:
IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179Rome, Italy Department of Internal Medicine and Public Health, University of L’Aquila, Piazzale Salvatore Tommasi 1, 67010L’Aquila-Coppito, Italy
E. Luders
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South, Los Angles, CA90095, USA
I.A. Rubino
Affiliation:
Neuroscience Department, University of Rome “Tor Vergata”, Via Montpellier, 1, 00133Rome, Italy
A. Siracusano
Affiliation:
Neuroscience Department, University of Rome “Tor Vergata”, Via Montpellier, 1, 00133Rome, Italy
G. Manfredi
Affiliation:
NESMOS Department, Faculty of Medicine and Psychology, University of Rome “Sapienza”, Rome, Italy
P. Girardi
Affiliation:
NESMOS Department, Faculty of Medicine and Psychology, University of Rome “Sapienza”, Rome, Italy
G. Martinotti
Affiliation:
Institute of Psychiatry, Catholic University of Sacred Heart, Rome, Italy
P.M. Thompson
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South, Los Angles, CA90095, USA
Y.-Y. Chou
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South, Los Angles, CA90095, USA
A.W. Toga
Affiliation:
Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South, Los Angles, CA90095, USA
C. Caltagirone
Affiliation:
IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179Rome, Italy Neuroscience Department, University of Rome “Tor Vergata”, Via Montpellier, 1, 00133Rome, Italy
G. Spalletta
Affiliation:
IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179Rome, Italy
*
*Corresponding author. Tel.: +39 06 51501215; fax: +39 06 51501213. E-mail address:[email protected] (M. Di Paola).
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Abstract

Abnormal brain connectivity has recently been reported in obsessive compulsive disorder (OCD). However, structural differences in the corpus callosum (CC), the primary structure connecting the two hemispheres, have not been extensively studied. In this case-control study, we recruited 30 patients with OCD and 30 healthy control subjects carefully matched for age, sex and handedness. Combining surface-based mesh-modeling and voxel-based morphometry (VBM), we compared callosal thickness and white matter (WM) density in patients and controls. We investigated associations between callosal structure and cortical gray matter (GM) density, and we related CC measures to neuropsychological performance in OCD. OCD patients showed small anterior and posterior callosal regions compared to healthy control subjects. In the OCD group, anterior callosal thickness was positively correlated with GM density of the right mid-dorso-lateral prefrontal (BA 9/46) area, while posterior callosal thickness was positively correlated with GM density in the left supramarginal gyrus (BA 40). Moreover, posterior callosal WM density was positively correlated with verbal memory, visuo-spatial memory, verbal fluency, and visuo-spatial reasoning performances. Callosal attributes were related to GM density in cortical areas innervated by the CC, and were also related to performance in cognitive domains impaired in the disorder. The CC may therefore be integrally involved in OCD.

Keywords

Corpus callosumRegion of interestVoxel-based morphometryDiffusion tensor imagingCortical gray matterNeuropsychological tests
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 8 , October 2013 , pp. 499 - 506
Copyright
Copyright © 2012 Elsevier Masson SAS

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