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St. John's wort versus depression

Published online by Cambridge University Press:  16 April 2020

C. Istikoglou ,
O. Mikirditsian ,
K. Michelidakis ,
T. Nikolaou ,
D. Vlissides ,
V. Mavreas ,
D. Damigos  and
M. Stathaki
C. Istikoglou
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece
O. Mikirditsian
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece
K. Michelidakis
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece
T. Nikolaou
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece
D. Vlissides
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece
V. Mavreas
Affiliation:
Medical School, University of Ioannina, Ioannina, Greece
D. Damigos
Affiliation:
Medical School, University of Ioannina, Ioannina, Greece
M. Stathaki
Affiliation:
Department of Psychiatry, Askleipeion of Voula, Athens, Greece

Abstract

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Introduction

The Hypericum Perforatum or Saint John's wort is an antidepressant herb, known since ancient times. It has been studied and is widely known mostly in the USA and in Germany due to its antidepressant qualities.

Purpose

Hypericum's pharmacodynamic and pharmacokinetic qualities as well as the investigation of its action mechanism.

Material – Method

The existing bibliography was studied, mostly from Medline with regard to the Hypericum's antidepressant action.

Effects

Comparative studies have been investigated with the use of questionnaires of the HAM-D, CGI and Von Zeersen of the action of Amitryptilline, Imipramine, Fluoxetine, fictitious medicine with the Hypericum.

Results:

The certain superiority of Hypericum to the fictitious medicine (Placebo) at its antidepressant action, as well as the action equality between the Hypericum and the known antidepressants Amitryptilline, Imipramine, Fluoxetine, and the certain superiority of Hypericum at its side-effects' low profile. In addition, it is verified that the Hypericum's effectiveness relates to its action at low or middle depression, since there are no pedantic studies for its effectiveness at heavy depression.

Type
Poster Session 2: Depressive Disorders
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S232
Copyright
Copyright © European Psychiatric Association 2007
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