Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-14T05:17:51.611Z Has data issue: false hasContentIssue false
  • English
  • Français

Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology

Published online by Cambridge University Press:  15 April 2020

S.-F. Chen ,
T.-M. Hu ,
T.-H. Lan ,
H.-J. Chiu ,
L.-Y. Sheen  and
E.-W. Loh
S.-F. Chen
Affiliation:
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan
T.-M. Hu
Affiliation:
Yu-Li Veterans Hospital, Yu-Li Town, Hualian County, Taiwan
T.-H. Lan
Affiliation:
Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan Faculty of Medicine, National Yang Ming University, Taipei, Taiwan Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan
H.-J. Chiu
Affiliation:
Faculty of Medicine, National Yang Ming University, Taipei, Taiwan Chung Hwa University of Medical Technology, Tainan, Taiwan Jianan Mental Hospital, Tainan, Taiwan
L.-Y. Sheen*
Affiliation:
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
E.-W. Loh*
Affiliation:
Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan
*
*Corresponding author. Institute of Food Science and Technology, National Taiwan University, Roosevelt Road Section 4, Taipei, Taiwan. Tel.: +886 2 3366 4129; fax: +886 2 2362 0849. E-mail addresses:[email protected] (L.-Y. Sheen)
**Corresponding author. Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, No.130, Kaisyuan 2nd Rd., Lingya Dist., Kaohsiung City 80276, Taiwan (R.O.C.). Tel: +886 7 751 3171; fax: +886 7 771 2494. E-mail addresses:[email protected] (E.-W. Loh).
Get access

Abstract

Background:

Metabolic abnormality is common among schizophrenia patients. Some metabolic traits were found associated with subgroups of schizophrenia patients.

Objectives:

We examined a possible relationship between metabolic abnormality and psychosis profile in schizophrenia patients.

Method:

Three hundred and seventy-two chronic schizophrenia patients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006.

Results:

Multiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology.

Conclusions:

Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome, especially the negative syndrome. Schizophrenia patients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain.

Keywords

SchizophreniaPsychosisMetabolismLipidGlucose
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 3 , March 2014 , pp. 167 - 171
Copyright
Copyright © European Psychiatric Association 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, NCNegative syndrome in schizophrenia: strategies for long-term management. Adv Biochem Psychopharmacol 1985;40:1–7.Google ScholarPubMed
Bai, YM, Lin, CC, Chen, JY, Lin, CY, Su, TP, Chou, PAssociation of initial antipsychotic response to clozapine and long-term weight gain. Am J Psychiatry 2006;163:1276–1279.CrossRefGoogle ScholarPubMed
Bellino, S, Rocca, P, Patria, L, Marchiaro, L, Rasetti, R, Di Lorenzo, Ret al.Relationships of age at onset with clinical features and cognitive functions in a sample of schizophrenia patients. J Clin Psychiatry 2004;65:908–914.CrossRefGoogle Scholar
Carpenter, WTJRClinical constructs and therapeutic discovery. Schizophr Res 2004;72:69–73.CrossRefGoogle ScholarPubMed
Cheng, JJ, Ho, H, Chang, CJ, Lane, HY, Hu, HGPositive and negative syndrome scale (PANSS): establishment and reliability study of a mandarin Chinese language version. Chin Psychiatry 1996;10:251–258.Google Scholar
Chien, IC, Hsu, JH, Lin, CH, Bih, SH, Chou, YJ, Chou, PPrevalence of diabetes in patients with schizophrenia in Taiwan: a population-based National Health Insurance study. Schizophr Res 2009;111:17–22.CrossRefGoogle ScholarPubMed
Chiu, HJ, Loh, EW, Lan, TH, Sou, JH, Hsieh, HC, Hu, TMIncrease of incidence of impaired fasting glucose in young schizophrenia patients. Psychiatry Clin Neurosci 2009;63:127–128.Google ScholarPubMed
Crow, TJMolecular pathology of schizophrenia: more than one disease process? Br Med J 1980;280:66–68.CrossRefGoogle ScholarPubMed
Crow, TJPositive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry 1980;137:383–386.CrossRefGoogle ScholarPubMed
Davidson, M, Harvey, PD, Powchik, P, Parrella, M, White, L, Knobler, HYet al.Severity of symptoms in chronically institutionalized geriatric schizophrenic patients. Am J Psychiatry 1995;152:197–207.Google ScholarPubMed
Fraguas, D, de Castro, MJ, Medina, O, Parellada, M, Moreno, D, Graell, Met al.Does diagnostic classification of early-onset psychosis change over follow-up?. Child Psychiatry Hum Dev 2008;39:137–145.CrossRefGoogle ScholarPubMed
Freeman, LR, Haley-Zitlin, V, Stevens, C, Granholm, ACDiet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus. Nutr Neurosci 2011;14:32–44.CrossRefGoogle ScholarPubMed
Hayashi, HLipid metabolism and glial lipoproteins in the central nervous system. Biol Pharm Bull 2011;34:453–461.CrossRefGoogle ScholarPubMed
Horrobin, DFThe membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr Res 1998;30:193–208.CrossRefGoogle ScholarPubMed
Horrobin, DF, Manku, MS, Hillman, H, Iain, A, Glen, MFatty acid levels in the brains of schizophrenics and normal controls. Biol Psychiatry 1991;30:795–805.CrossRefGoogle ScholarPubMed
Huang, MC, Lu, ML, Tsai, CJ, Chen, PY, Chiu, CC, Jian, DLet al.Prevalence of metabolic syndrome among patients with schizophrenia or schizoaffective disorder in Taiwan. Acta Psychiatr Scand 2009;120:274–280.CrossRefGoogle ScholarPubMed
Hung, CF, Wu, CK, Lin, PYDiabetes mellitus in patients with schizophrenia in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:523–527.CrossRefGoogle ScholarPubMed
Kao, YC, Liu, YPEffects of age of onset on clinical characteristics in schizophrenia spectrum disorders. BMC Psychiatry 2010;10:63.CrossRefGoogle ScholarPubMed
Kay, SR, Opler, LAThe positive-negative dimension in schizophrenia: its validity and significance. Psychiatr Dev 1987;5:79–103.Google ScholarPubMed
Meltzer, HY, Perry, E, Jayathilake, KClozapine-induced weight gain predicts improvement in psychopathology. Schizoph Res 2003;59:19–27.CrossRefGoogle ScholarPubMed
Meltzer, HY, Bobo, WV, Lee, MA, Cola, P, Jayathilake, KA randomized trial comparing clozapine and typical neuroleptic drugs in non-treatment-resistant schizophrenia. Psychiatry Res 2010;177:286–293.CrossRefGoogle ScholarPubMed
Procyshyn, RM, Wasan, KM, Thornton, AE, Barr, AM, Chen, EY, Pomarol-Clotet, Eet al.Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment. J Psychiatry Neurosci 2007;32:331–338.Google ScholarPubMed
Richardson, AJ, Allen, SJ, Hajnal, JV, Cox, IJ, Easton, T, Puri, BKAssociations between central and peripheral measures of phospholipid breakdown revealed by cerebral 31-phosphorus magnetic resonance spectroscopy and fatty acid composition of erythrocyte membranes. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:1513–1521.CrossRefGoogle ScholarPubMed
Saari, K, Jokelainen, J, Veijola, J, Koponen, H, Jones, PB, Savolainen, Met al.Serum lipids in schizophrenia and other functional psychoses: a general population northern Finland 1966 birth cohort survey. Acta Psychiatr Scand 2004;110:279–285.CrossRefGoogle ScholarPubMed
Saari, K, Lindeman, S, Koponen, H, Jokelainen, J, Isohanni, MHigher serum triglyceride levels in early-onset schizophrenia. Am J Psychiatry 2004;161:176.CrossRefGoogle ScholarPubMed
Sethom, MM, Fares, S, Bouaziz, N, Melki, W, Jemaa, R, Feki, Met al.Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. Prostaglandins Leukot Essent Fatty Acids 2010;83:131–136.CrossRefGoogle ScholarPubMed
Stranahan, AM, Cutler, RG, Button, C, Telljohann, R, Mattson, MPDiet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress. J Neurochem 2011;118:611–615.CrossRefGoogle ScholarPubMed
Wainwright, PEDietary essential fatty acids and brain function: a developmental perspective on mechanisms. Proc Nutr Soc 2002;61:61–69.CrossRefGoogle Scholar
Williams, PT, Stefanick, ML, Vranizan, KM, Wood, PDThe effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med 1991;325:461–466.Google Scholar
Williams, PT, Stefanick, ML, Vranizan, KM, Wood, PDThe effects of weight loss by exercise or by dieting on plasma high-density lipoprotein (HDL) levels in men with low, intermediate, and normal-to-high HDL at baseline. Metabolism 1994;43:917–924.CrossRefGoogle ScholarPubMed
Wood, PD, Stefanick, ML, Dreon, DM, Frey-Hewitt, B, Garay, SC, Williams, PTet al.Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1998;319:1173–1179.CrossRefGoogle Scholar
Yang, YW, Fu, CYTwo advanced methods for adjusting the main coefficient in logistic regression. Comput Stat 2013;28:199–218.CrossRefGoogle Scholar
Yao, JK, Leonard, S, Reddy, RDMembrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schizophr Res 2000;42:7–17.CrossRefGoogle ScholarPubMed
Yao, J, Stanley, JA, Reddy, RD, Keshavan, MS, Pettegrew, JWCorrelations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites. Biol Psychiatry 2002;52:823–830.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.