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Serum beta2-microglobulin as a possible early indicator of glomerular filtration impairment in subjects receiving long-term lithium treatment

Published online by Cambridge University Press:  16 April 2020

G Rutigliano  and
F Vadruccio
G Rutigliano
Affiliation:
Center of Psychopharmacotheropy, University of Bari, Psychiatric Clinic-Policlinic, 11 piazza G Cesare, 70124Bari, Italy
F Vadruccio
Affiliation:
Center of Psychopharmacotheropy, University of Bari, Psychiatric Clinic-Policlinic, 11 piazza G Cesare, 70124Bari, Italy
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Summary

Serum β2-microglobulin (β2m) levels were increased in ten out of 52 patients on chronic lithium treatment, while creatinine levels were within the normal range in all of them and creatinine clearance was below the normality in only five. We propose serum β2m assessment as a possible precocious indicator of glomerular filtration impairment, and recommend its frequent determination in patients chronically treated with lithium to prevent the occurrence of renal insufficiency.

Keywords

β2-microgloubulinkidney damagelithium
Type
Short communication
Information
European Psychiatry , Volume 9 , Issue 4 , 1994 , pp. 201 - 203
Copyright
Copyright © European Psychiatric Association 1994

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