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Serotonin Transporter Concentration is Decreased in Cerebral Cortex but not in Striatum of Chronic MDMA (ecstasy) Users

Published online by Cambridge University Press:  16 April 2020

S.J. Kish ,
T. McCluskey ,
J. Meyer ,
J.J. Warsh ,
D. Wilkins ,
A.A. Wilson  and
S. Houle
S.J. Kish
Affiliation:
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
T. McCluskey
Affiliation:
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
J. Meyer
Affiliation:
PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
J.J. Warsh
Affiliation:
Laboratory of Cellular and Molecular Pathophysiology, Centre for Addiction and Mental Health, Toronto, Canada
D. Wilkins
Affiliation:
Center for Human Toxicology, University of Utah, Salt Lake City, USA
A.A. Wilson
Affiliation:
PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
S. Houle
Affiliation:
PET Centre, Centre for Addiction and Mental Health, Toronto, Canada

Abstract

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Background:

Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is an amphetamine derivative that is used recreationally and is now being tested in clinical trials for treatment of posttraumatic stress disorder. Ecstasy can damage serotonin neurones in brain of experimental animals; however, relevance of these findings to the human is debated.

Aim:

To measure by positron emission tomography (PET) levels of binding to the serotonin transporter (SERT), a marker of serotonin neurones, in brain of chronic ecstasy users and in matched controls.

Methods:

An estimate of brain SERT levels was obtained, using the PET tracer 11C-DASB, in 50 chronic (confirmed by drug hair testing) ecstasy users (mean age, 26 years; mean duration of drug use, 3.9 years; median drug withdrawal time, 38 days) and 50 (drug-hair negative) control subjects (mean age 26 years).

Results:

SERT binding levels in the ecstasy group were significantly decreased by 22 to 46% in frontal, temporal, cingulate, insular and occipital cortices, and by 23% in hippocampus. However, concentrations were distinctly normal in the SERT-rich caudate, putamen, ventral striatum and thalamus.

Conclusion:

Our imaging data suggest that cerebral cortical SERT concentration is below normal in some ecstasy users for at least one month after last use of the drug. However, it remains to be established whether low SERT might have preceded drug use, reflects actual loss of brain serotonin neurones, or is causally related to any functional impairment in the ecstasy users. (Supported by US NIH NIDA DA017301).

Type
P01-46
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E434
Copyright
Copyright © European Psychiatric Association 2009
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