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Sensation seeking, alcoholism and dopamine activity

Published online by Cambridge University Press:  16 April 2020

GA Wiesbeck ,
N Wodarz ,
C Mauerer ,
J Thome ,
F Jakob  and
J Boening
GA Wiesbeck
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
N Wodarz
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
C Mauerer
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
J Thome
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
F Jakob
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
J Boening
Affiliation:
Psychiatric University Clinic, Addiction Research Group, University of Wuerzburg, Fuechsleinstr 15, 97080Wuerzburg, Germany
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Summary

Sensation seeking scale (SSS) scores were determined in 15 alcohol dependent men with a positive family history for alcoholism (FHP), in 15 alcohol dependent men with a negative family history for alcoholism (FHN) and in 15 well-matched healthy male controls (CONTR). Both FHPs and FHNs suffered from longlasting alcohol dependence meeting ICD-10 and DSM-III-R diagnostic criteria. Dopamine activity was neuroendocrinologically assessed by measuring the amount of growth hormone released after stimulation with the dopamine receptor agonist apomorphine. Planned comparisons within a one-way ANOVA yielded significantly elevated levels of boredom susceptibility (BOS) in both FHPs and FHNs against CONTRs. SSS total scores, while approaching statistical significance, were elevated in FHPs only. Partial correlations (controlling for age, body weight, alcohol intake and duration of dependence) were calculated to examine the relationship between SSS and dopamine activity. Among the SSS subtraits, BOS revealed the highest correlation in each group. However, only in CONTRs did the relationship between BOS and dopamine activity reach statistical significance.

Keywords

sensation seekingalcohol dependencedopamine receptor sensitivityfamily history for alcoholism
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 2 , 1996 , pp. 87 - 92
Copyright
Copyright © Elsevier, Paris 1996

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References

Balldin, JAlling, CGottfries, CGLindstedt, GLangstroem, GChanges in dopamine receptor sensitivity in humans after heavy alcohol intake Psychopharmacology 1985 86 142–146CrossRefGoogle ScholarPubMed
Balldin, JBerggren, ULindstedt, GNeuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism Alcohol Clin Exp Res 1992 16 71–74CrossRefGoogle ScholarPubMed
Balldin, JBerggren, ULindstedt, GSundkler, AFurther neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholism Drug Alcohol Depend 1993 32 159–162CrossRefGoogle ScholarPubMed
Baker, KBeer, JBeer, JSelf-esteem, alcoholism, sensation seeking, GPA, and differential aptitude test scores of high school students in an honor society Psychological Rep 1991 69 11471150CrossRefGoogle Scholar
Bates, MELobouvie, EWWhite, HRThe effect of sensation seeking needs on alcohol and marijuana use in adolescence Bull Soc Psychol Addict Behav 1986 5 29–36Google Scholar
Bozarth, MAEvidence for the rewarding effects of ethanol using the conditioned place preference method Pharmacol Biochem Behav 1991 35 485–487CrossRefGoogle Scholar
Calhoon, LLSensation seeking, exercise, and dopamine beta hydroxylase Personality Individ Differ 1991 12 903907CrossRefGoogle Scholar
Calhoon, LLExplorations into the biochemistry of sensation seeking Personality Individ Differ 1988 9 941–949CrossRefGoogle Scholar
Carton, SJouvent, RWidlöcher, DCross-cultural validity of the Sensation Seeking Scale: development of a French abbreviated form Eur Psychiatry 1992 7 225–234CrossRefGoogle Scholar
Diana, MGessa, GLRosetti, ZLLack of tolerance to ethanolinduced stimulation of mesolimbic dopamine system Alcohol Alcoholism 1992 4 329–333Google Scholar
DiChiarra, GImperato, ADrugs abused by humans preferentially increase synaptic dopamine concentration in the mesolimbic system of freely moving rats Proc Natl Acad Sci USA 1988 85 5274–5278CrossRefGoogle Scholar
DiChiarra, GGessa, LGPharmacology and neurochemistry of apomorphineGarattini, SGoldin, AHawkin, FKopin, IJAdvances in Pharmacology and Chemotherapy New York, San Francisco, LondonAcademic Press 1978 15 87–143Google Scholar
Earleywine, MFinn, PRSensation seeking explains the relation between behavorial disinhibition and alcohol consumption Addict Behav 1991 16 123–128CrossRefGoogle Scholar
Feuerlein, WRinger, CKuefner, HAnton, KDiagnose des Alkoholismus-Der Muenchner Alkoholismus Test (MALT) Muench Med Wschr 1977 119 1275–1282Google Scholar
Galizio, MGerstenhaber, LFriedensen, FCorrelates of sensa-tion seeking in alcoholics Int J Addict 1985 20 1479–1493CrossRefGoogle ScholarPubMed
Gessa, GLMuntone, FCollu, MVargiu, LMereu, GPLow doses of ethanol activate dopaminergic neurons in the ventral tegmental area Brain Res 1985 348 201–203CrossRefGoogle ScholarPubMed
Kilpatrick, DGAging, alcoholism, anxiety, and sensation seeking: an exploratory investigation Addict Behav 1982 7 97–100CrossRefGoogle Scholar
Kraft, PRise, JThe relationship between sensation seeking and smoking, alcohol consumption and sexual behavior among Norwegian adolescents Health Educ Res 1994 9 193–200CrossRefGoogle Scholar
Kohn, PMCoulas, JTSensation seeking, augmenting-reducing and the perceived and preferred effects of drugs J Pers Soc Psychol 1985 99–106CrossRefGoogle ScholarPubMed
Lal, Sde la Vega, CESourkes, TLFriesen, HGEffect of apomorphine on human-growth-hormone secretion Lancet 1972 661CrossRefGoogle ScholarPubMed
Lal, SApomorphine in the evaluation of dopaminergic function in man Prog Neuropsychopharmacol Biol Psychiatry 1988 12 117–164CrossRefGoogle ScholarPubMed
Maany, IFrazer, AMendels, JApomorphine: effect on growth hormone J Clin Endocrin Metab 1975 40 162–163CrossRefGoogle ScholarPubMed
Meister, BHokfelt, TVale, WWGoldstein, MGrowth hormone releasing factor (GRF) and dopamine coexist in hypothalamic arcuate neurones Acta Physiol Scan 1985 124 133136CrossRefGoogle Scholar
Netter, PRammsayer, TReactivity to dopaminergic drugs and aggression related personality traits Pers Ind Diff 1991 12 1009–1017CrossRefGoogle Scholar
Schuckit, MAA clinical model of genetic influences in alcohol dependence J Studies Alcohol 1994 55 517CrossRefGoogle ScholarPubMed
Sourkes, TL, Lal, SApomorphine and its relation to dopamine in the nervous system Adv Neurochem 1975 1 247–299CrossRefGoogle Scholar
Wise, RARompre, PPBrain dopamine and reward Ann Rev Psychol 1989 40 191–225CrossRefGoogle ScholarPubMed
Yoshimoto, KMcBride, JLumeng, LLi, TKEthanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats Alcohol Clin Exp Res 16 1992 781–785CrossRefGoogle ScholarPubMed
Zuckerman, MTheoretical formulationsZubeck, JPSensory Deprivation: fifteen Years of Research New YorkAppleton-Century 1969 407–432Google Scholar
Zuckerman, MSensation seeking and psychopathyHare, RDSchalling, DPsychopathic Behavior. Approaches to Research New YorkWiley 1978 165–185Google Scholar
Zuckerman, MSensation seeking: beyond the optimal level of arousal Hillsdale, NJLawrence Erlbaum 1979Google Scholar
Zuckerman, MA biological theory of sensation seekingZuckerman, MBiological Bases of Sensation Seeking,Impulsivity, and Anxiety HillsdaleErlbaum 1983 37–76Google Scholar
Zuckerman, MPsychobiology of Personality New YorkCambridge University Press 1991Google Scholar
Zuckerman, MImpulsive unsocialized sensation seeking: the biological foundations of a basic dimension of personalityBates, JEWachs, TDTemperament: individual differences at the interface of biology and behavior Washington DCAmerican Psychological Association, APA science volumes 1994 219–255CrossRefGoogle Scholar
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