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Searching for a predictive peripherical biological model in parasuicidal behaviour

Published online by Cambridge University Press:  16 April 2020

PA Sáiz ,
J Bobes ,
MP González ,
I Cocaña ,
P González-Quiros  and
M Bousoño
PA Sáiz
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
J Bobes*
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
MP González
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
I Cocaña
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
P González-Quiros
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
M Bousoño
Affiliation:
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería n° 633006 Oviedo, Spain
*
*Correspondence and reprint.
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Summary

The aim of this study was to identify possible peripheral biological markers (both lipidic and hormonal) which can be easily used for the early detection of parasuicidal behaviour and to propose a predictive biological model of such behaviour. A case-control analytical study was undertaken at least 3 months after attempted suicide. Study was made of 128 patients who presented at the University General Hospital of Oviedo (Spain) with signs of self-intoxication. Lipidic and hormonal profiles were measured under basal conditions and comparison was made with a control group of healthy volunteer donors obtained from the Oviedo General Hospital blood bank. A discriminant analysis was later made with the aim of establishing a predictive biological model. This included the following variables: cholesterol, HDL-C, LDL-C and cortisol. Sensitivity and specificity were 62.5% and 65.6%, respectively. Replication and improvement of this model, through other prospective studies, could lead to the use of serum cholesterol and cortisol levels as inexpensive and readily available markers of suicide risk.

Keywords

parasuicidal behaviourbiological markerscholesterolcortisol
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 2 , 1997 , pp. 75 - 81
Copyright
Copyright © Elsevier, Paris 1997

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