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Schizotypal Traits are Associated with Decreased Functional Connectivity between Medial Prefrontal Cortex and Cerebellum in a Non-clinical Sample

Published online by Cambridge University Press:  01 September 2022

Y. Panikratova ,
E. Abdullina ,
E. Pechenkova  and
I. Lebedeva
Y. Panikratova
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
E. Abdullina*
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
E. Pechenkova
Affiliation:
Higher School of Economics, Laboratory For Cognitive Research, Moscow, Russian Federation
I. Lebedeva
Affiliation:
Mental Health Research Center, Laboratory Of Neuroimaging And Multimodal Analysis, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Schizotypy is associated with increased vulnerability to schizophrenia spectrum disorders. Therefore, investigation of its brain correlates seems prominent for better understanding of schizophrenia-spectrum continuum as well as for development of biological treatments for schizotypal personality disorder. Functional alterations of prefrontal cortex (PFC) and their associations with clinical symptoms are well-known to exist in schizophrenia. However, their relevance to schizotypy remains unclear.

Objectives

The aim of the study was to check for associations between schizotypal traits in a non-clinical sample and whole-brain functional connectivity (FC) of lateral as well as medial PFC (lPFC and mPFC, respectively).

Methods

Eighty-two healthy individuals (52 females, mean age 24.8±5.48) filled out the Schizotypal Personality Questionnaire (SPQ-74) and underwent resting-state fMRI (3T). Seeds in lPFC and mPFC were taken from frontoparietal and default mode networks (atlas by Yeo et al., 2011). We analyzed correlations between four schizotypal factors (cognitive/perceptual, paranoid, negative, and disorganization; Stefanis et al., 2004) and whole-brain FC of the seeds (statistical threshold: p<.001 voxelwise; p[FDR]<.05 clusterwise).

Results

Cognitive/perceptual factor (‘Odd beliefs/magical thinking’ and ‘Unusual perceptual experiences’ SPQ-74 subscales) is negatively correlated to FC of bilateral mPFC with a cluster in the right cerebellum (Crus 1, 2).

Conclusions

Prefrontal-cerebellar dysconnectivity may be one of the neurobiological factors underlying positive-symptoms-like schizotypal traits in non-clinical subjects. To some extent, it coincides with the data on associations between functional features of these brain structures and positive symptoms in schizophrenia (Pinheiro et al., 2021; Goghari et al., 2010).

Disclosure

The study was supported by RFBR Grant 20-013-00748.

Keywords

resting-state fMRIschizotypySPQ-74
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S214
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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