Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-19T23:10:35.305Z Has data issue: false hasContentIssue false
  • English
  • Français

S55.03 - Transition to psychosis: Neuropsychological test results of the epos study

Published online by Cambridge University Press:  16 April 2020

D.H. Linszen ,
D.H. Nieman ,
H.E. Becker ,
J.R. van de Vliert ,
P.M. Dingemans ,
J. Klosterkoetter ,
M. Birchwood ,
R.K. Salokangas ,
S. Ruhrmann  and
G. Juckel
...Show all authors
D.H. Linszen
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
D.H. Nieman
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
H.E. Becker
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
J.R. van de Vliert
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
P.M. Dingemans
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
J. Klosterkoetter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
R.K. Salokangas
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Central Hospital, Turku, Finland
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
G. Juckel
Affiliation:
Department of Psychiatry, Ruhr-University of Bochum, LWL-Klinik, Bochum, Germany
A. Morrison
Affiliation:
Department of Psychiatry, Victoria University of Manchester, Manchester, UK
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
M. Heinimaa
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Central Hospital, Turku, Finland
H. Graf von Reventlow
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
the EPOS Group
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands Department of Psychiatry, Victoria University of Manchester, Manchester, UK

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction:

Both schizophrenia and ultra high risk (UHR) patients show reduced neurocognitive performance compared to matched healthy control subjects. In the current study we compared neurocognitive performance at baseline and follow up between UHR patients who made the transition to psychosis and patients who did not.

Method:

Patients were eligible for the study when they met criteria for one or more of the following groups: Attenuated symptoms or brief limited intermitted psychotic symptoms or a first degree family member with a psychotic disorder and reduced functioning or basic symptoms. We assessed 216 UHR patients (166 males, mean age: 22,6 SD 5,2) with a neuropsychological test battery composed of the National adult reading test (premorbid IQ), California verbal memory test (verbal memory), spatial working memory test, verbal fluency first letter and categories (executive functioning), finger tapping test (motor speed) and continuous performance test (sustained attention). Data were collected in 7 participating centres of EPOS. Follow up was at 9 months.

Results:

37 UHR patients made the transition to psychosis (25 males, mean age 21,5 SD 4,8). The only test that showed a significant difference between the transition and non transition group at baseline was verbal fluency categories (t= 2.79, p = 0.006).

Conclusion:

Patients who later make the transition to psychosis perform significantly worse on verbal fluency categories than patients who do not make the transition to psychosis. Verbal fluency may contribute to an improved prediction of psychosis in UHR patients. Follow up results will also be presented.

Type
9 April 2008 Symposium: EPOS - further results of the completed study
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S68 - S69
Copyright
Copyright © European Psychiatric Association 2008
Submit a response

Comments

No Comments have been published for this article.