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S55.02 - Subjective quality of life and its changes in patients at risk of psychosis

Published online by Cambridge University Press:  16 April 2020

R.K. Salokangas ,
M. Heinimaa ,
T. Svirskis ,
J. Klosterkoetter ,
S. Ruhrmann ,
H. Graf von Reventlow ,
D.H. Linszen ,
P.M. Dingemans ,
M. Birchwood  and
P. Patterson
...Show all authors
R.K. Salokangas
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Hospital, Turku, Finland
M. Heinimaa
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Hospital, Turku, Finland
T. Svirskis
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Hospital, Turku, Finland
J. Klosterkoetter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
H. Graf von Reventlow
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, University Hospital of Cologne, Cologne, Germany
D.H. Linszen
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
P.M. Dingemans
Affiliation:
Academisch Psychiatrisch Centrum, Academic Medical Centre, Adolescentenkliniek, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
G. Juckel
Affiliation:
Department of Psychiatry, Ruhr-University of Bochum, LWL-Klinik, Bochum, Germany
A. Morrison
Affiliation:
Department of Psychology, Victoria University of Manchester, Manchester, UK
the EPOS Group
Affiliation:
Psychiatric Clinic, University of Turku, Turku University Hospital, Turku, Finland Department of Psychology, Victoria University of Manchester, Manchester, UK

Abstract

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Objectives:

The European Prediction of Psychosis Study (EPOS) aimed to study a large sample of young patients who are at risk of psychosis and to estimate their conversion rate to psychosis during 18 months follow-up. This presentation describes quality of life and its changes in patients at risk of psychosis.

Methods:

In six European centres, 16 to 35 year old psychiatric patients were examined. Risk of psychosis was defined by occurrence of basic symptoms, attenuated psychotic symptoms, brief, limited or intermittent psychotic symptoms or familial risk plus reduced functioning. Quality of life (QoL), measured by the Modular System for Quality of Life, was assessed at baseline and at 9 and 18 months’ follow-ups. Psychiatric patients without prodromal symptoms and healthy subjects were comparison groups.

Results:

In all, 245 risk patients were included. At baseline, they reported lower QoL than non-risk patients and healthy controls. Basic symptoms associated negatively with QoL, and there were differences between the study centres. During the follow-up, QoL raised less in risk patients than in non-risk patients. Baseline QoL did not predict transition to psychosis. However, its development was poorer in patients with than in those without transition to psychosis.

Conclusions:

Those of the psychiatric patients who are at risk of psychosis have lower QoL than other psychiatric patients or healthy controls. QoL does not predict transition to psychosis, but its changes correlates with changes in clinical state. The results indicate that there is a need for comprehensive intervention with the patients at risk of psychosis.

Type
9 April 2008 Symposium: EPOS - further results of the completed study
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S68
Copyright
Copyright © European Psychiatric Association 2008
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