Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-18T14:44:10.886Z Has data issue: false hasContentIssue false
  • English
  • Français

S35-01 - Clinical Influencing Factors of Acute Treatment Outcome in First-Episode Schizophrenia Patients

Published online by Cambridge University Press:  17 April 2020

R. Schennach-Wolff ,
F. Seemüller ,
A. Mayr ,
W. Maier ,
G. Buchkremer ,
I. Heuser ,
J. Klosterkötter ,
M. Gastpar ,
H. Häfner  and
H. Sauer
...Show all authors
R. Schennach-Wolff
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich
F. Seemüller
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich
A. Mayr
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich
W. Maier
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn
G. Buchkremer
Affiliation:
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen
I. Heuser
Affiliation:
Department of Psychiatry and Psychotherapy, Charite Berlin, Berlin
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne
M. Gastpar
Affiliation:
Department of General Psychiatry, Rhein Hospital Essen, Essen
H. Häfner
Affiliation:
Central Institute od Mental Health, Mannheim
H. Sauer
Affiliation:
Department of Psychiatry and Psychotherapy, University of Jena, Jena
F. Schneider
Affiliation:
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen
W. Gaebel
Affiliation:
Department of Psychiatry and Psychotherapy, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
H.-J. Moeller
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich
M. Riedel
Affiliation:
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Munich, Munich

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background

Aim was to evaluate influencing factors of response and symptomatic remission in first-episode schizophrenia patients treated with risperidone or haloperidol.

Methods

229 first-episode schizophrenic patients were examined within a double blind controlled trial of the German Study Group on first-episode schizophrenia with biweekly PANSS ratings. Response was defined according to the definition by Lieberman et al. (2003) and symptomatic remission as the severity component of the consensus remission criteria by the Remission in Schizophrenia Working Group. Sociodemographic, psychopathological and functional variables as well as the treatment applied were evaluated regarding their potential predictive validity for treatment outcome. Univariate tests, logistic regression and CART-analyses were consulted as statistical methods.

Results

126 patients (55%) achieved response and 118 patients (52%) symptomatic remission at discharge with no significant differences between the risperidone (51%) and haloperidol (49%) treated patients. Better baseline functioning, early treatment response, less depressive symptoms and a shorter duration of untreated psychosis were revealed significant predictors of response. Patients with symptomatic remission also had a significantly shorter duration of untreated psychosis and significantly less depressive symptoms at baseline. Logistic regression and CART-analyses revealed low general psychopathology, early treatment response and a high score in the Strauss-Carpenter-Prognostic-Scale at admission to be significantly positive predictive for symptomatic resolution.

Conclusion

Early treatment response, depressive symptoms and the level of psychosocial functioning were revealed to significantly predict outcome, with no significant differences between risperidone and haloperidol. The importance of an early adequate symptom control and the implementation of early intervention programs is highlighted.

Type
Positive and negative influencing factors of treatment outcome in first-episode schizophrenia patients
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E65
Copyright
Copyright © European Psychiatric Association 2010
Submit a response

Comments

No Comments have been published for this article.