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S32.01 - Uncinate fasciculus and cingulum bundle findings in first episode schizophrenia and first episode bipolar disorder: A diffusion tensor imaging study

Published online by Cambridge University Press:  16 April 2020

M.E. Shenton ,
T. Kawashima ,
M. Nakamura ,
S. Bouix ,
D.F. Salisbury ,
C.F. Westin ,
R.W. McCarley  and
M. Kubicki
M.E. Shenton
Affiliation:
Psychiatry and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
T. Kawashima
Affiliation:
Department of Psychiatry, VA Boston Healthcare System and Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
M. Nakamura
Affiliation:
Department of Psychiatry, Yokahama City University of Medicine, Yokahama, Japan
S. Bouix
Affiliation:
Psychiatry and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
D.F. Salisbury
Affiliation:
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
C.F. Westin
Affiliation:
Psychiatry and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
R.W. McCarley
Affiliation:
Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
M. Kubicki
Affiliation:
Psychiatry and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA

Abstract

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Background and Aims:

Fronto-temporal connections have long been thought to be involved in schizophrenia. Two fronto-temporal connections of interest are uncinate fasciculus (UF) and cingulum bundle (CB), which recently have been investigating using Diffusion Tensor Imaging (DTI), a new technique that affords an opportunity to evaluate white matter fiber integrity in vivo. Using this technique, we previously reported abnormalities in UF and CB in chronic patients. Additionally, we noted that schizotypal personality disordered subjects showed UF but not CB abnormalities.

Methods:

Here, we sought to determine whether or not UF and CB white matter integrity are altered at initial onset of illness, and are specific to schizophrenia. We evaluated twelve first-episode schizophrenia, 12 first-episode affective psychosis and 12 controls using DTI on a 1.5T magnet. Fractional anisotropy (FA) and mean diffusivity (Dm) were used to quantify water diffusion, and cross-sectional area was defined with a directional threshold method.

Results:

Findings showed bilateral reduction of UF FA, but not Dm, in first-episode schizophrenia compared with controls and first-episode affective psychotic patients. For CB, there were no statistically significant group differences for either FA or Dm.

Discussion:

These findings suggested that UF white matter integrity, but not CB white matter integrity, is altered at initial onset of schizophrenia and may be specific to schizophrenia. In contrast, CB abnormalities are not present at first episode of schizophrenia and may reflect progressive changes that occur over the course of the illness. The latter will need to be investigated using a longitudinal design.

Type
Symposium: Altered white matter communication in schizophrenia and bipolar disorder: A possible common endophenotype?
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S43
Copyright
Copyright © European Psychiatric Association 2008
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