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S21.01 - Attention deficit/hyperactivity disorder and dyslexia: evidence for shared genetic susceptibility

Published online by Cambridge University Press:  16 April 2020

C.L. Barr ,
K. Wigg ,
N. Laurin ,
V. Misener ,
T. Cate-Carter ,
L.W. Maureen ,
E. Kerr  and
J. Couto
C.L. Barr
Affiliation:
Genetics and Development Division, The Toronto Western Hospital, Toronto, ON, Canada Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
K. Wigg
Affiliation:
Genetics and Development Division, The Toronto Western Hospital, Toronto, ON, Canada
N. Laurin
Affiliation:
Genetics and Development Division, The Toronto Western Hospital, Toronto, ON, Canada
V. Misener
Affiliation:
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
T. Cate-Carter
Affiliation:
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
L.W. Maureen
Affiliation:
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
E. Kerr
Affiliation:
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada
J. Couto
Affiliation:
Genetics and Development Division, The Toronto Western Hospital, Toronto, ON, Canada

Abstract

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Objective:

Many individuals ascertained for developmental dyslexia (DD) are also diagnosed with attention-deficit hyperactivity disorder (ADHD) and approximately 20% of individuals with ADHD will have evidence for DD. The basis for this overlap is not completely understood but twin studies have provide support for common genetic influences, particularly for inattention symptoms. Genetic linkage studies have found significant evidence for linkage of DD to chromosomes 1p34-p36, 15q, 6p21.3-22, 2p15-16, 6q11.2-q12 and 18p11.2. Evidence for linkage/association to ADHD has also been found to overlap for some of these regions. The objective of this study is to identify genes contributing to both.

Methods:

We examined evidence for the involvement of specific genes in these chromosomal regions using two samples of families, one ascertained through a proband with DD (n= 273 families) and the other through a proband with ADHD (n= 390 families).

Results:

Our studies of the 6p region indicate that the sample of DD families is associated to markers in this region and to ADHD but not to the same markers within the linked region. For the 15q region, we have found significant evidence for association for both the ADHD and reading phenotypes in both samples (Wigg et al., 2004; Wigg et al., 2005). We have also found evidence for the gene for the dopamine receptor D1 to be associated to the inattention symptoms in both samples

Conclusions:

While the studies of the overlap in ADHD and DD are preliminary, they are promising in that they will ultimately help to disentangle the causal relationship.

Type
Research Article
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S25 - S26
Copyright
Copyright © European Psychiatric Association 2008

References

Wigg, K, Couto, J, Feng, Y, Crosbie, J, Anderson, B, Cate-Carter, TD, Tannock, R, Lovett, MW, Humphries, T, Kennedy, JL, Ickowicz, A, Pathare, T, Roberts, W, Malone, M, Schachar, R, Barr, CL. 2005. Investigation of the relationship of attention deficit hyperactivity disorder to the EKN1 gene on chromosome 15q21. Scientific Studies of Reading 9(3): 261–283.10.1207/s1532799xssr0903_5CrossRefGoogle Scholar
Wigg, KG, Couto, JMFeng, Y, Anderson, B, Cate-Carter, TD, Macciardi, F, Tannock, RLovett, MW, Humphries, T, Barr, CL. 2004. Support for EKN1 as the susceptibility locus for dyslexia on 15q21. Mol Psychiatry 13: 13.10.1038/sj.mp.4001543CrossRefGoogle Scholar
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