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The role of subclinical depressive symptomatology during the prenatal period in cortisol rhythm alterations and postpartum depression risk

Published online by Cambridge University Press:  01 September 2022

Á. Castro Quintas ,
M. Daura-Corral ,
E. Eixarch ,
F. Crispi ,
L. De La Fuente Tomas ,
M. Rocavert Barranco ,
A. Miguel Valero ,
L. Marques Feixa ,
H. Palma Gudiel  and
M.P. Garcia-Portilla
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Á. Castro Quintas*
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
M. Daura-Corral
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain
E. Eixarch
Affiliation:
Maternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, Spain
F. Crispi
Affiliation:
Maternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, Spain
L. De La Fuente Tomas
Affiliation:
University of Oviedo, Department Of Psychiatry, Oviedo, Spain
M. Rocavert Barranco
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain
A. Miguel Valero
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain
L. Marques Feixa
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
H. Palma Gudiel
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
M.P. Garcia-Portilla
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain University of Oviedo, Department Of Psychiatry, Oviedo, Spain
L. Fañanas
Affiliation:
University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
*
*Corresponding author.

Abstract

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Introduction

Cortisol, the hormonal endpoint of Hypothalamic Pituitary Adrenal (HPA) axis, coordinates the body response in front of daily stressful situations. Disturbances in cortisol circadian rhythm have been implicated in the pathophysiology of depression and neurodevelopment lasting consequences. Although pregnancy entails a progressively increase in cortisol levels, the consequences of subclinical depression traits during pregnancy in cortisol circadian rhythm remains unclear.

Objectives

To analyze the impact of prenatal subclinical depressive symptomatology in cortisol circadian rhythm through pregnancy and its relevance for postpartum depression risk.

Methods

A cohort of 112 healthy pregnant women (Mean age±SD=32.32±4.37) of the general population was followed throughout their first pregnancy and first two months of postpartum period. Diurnal salivary cortisol curve (four measures) was obtained for every trimester; the Area Under the Curve with respect to the ground (AUCg) and with respect to the increase (AUCi) were used as measures of basal HPA axis functioning. Depressive symptomatology was assessed every pregnancy trimester and postpartum period following EPDS criteria. All the analyses were adjusted for maternal age, weight, ethnicity and socioeconomic status and sample collection’s time.

Results

Prenatal subclinical depressive symptomatology (EPDS>10) was associated with a blunted cortisol rhythm during first trimester (F= 3.913,p=.011) but not during second (F=2.629, p=056) or third trimesters (F=.411,p=.724). Furthermore, a logistic regression model showed a positive association between Prenatal subclinical depressive symptomatology and the risk of postpartum depression (χ2=13.8, p<.001,OR=9.6; 95%CI 2.5–35.5).

Conclusions

Women with subclinical depressive symptomatology in early pregnancy had alterations in cortisol circadian rhythmicity and a higher risk of postpartum depression.

Disclosure

No significant relationships.

Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S102 - S103
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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