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Role of dopamine in non-depressed patients with a history of suicide attempts

Published online by Cambridge University Press:  16 April 2020

W. Pitchot ,
M. Hansenne  and
M. Ansseau
W. Pitchot*
Affiliation:
Psychiatric Unit, CHU Sart Tilman, B-4000Liège, Belgium
M. Hansenne
Affiliation:
Psychiatric Unit, CHU Sart Tilman, B-4000Liège, Belgium
M. Ansseau
Affiliation:
Psychiatric Unit, CHU Sart Tilman, B-4000Liège, Belgium
*
*Correspondence and reprints.
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Summary

Several data are available about the implication of the dopaminergic system in the control of inward-directed aggression. Previously, we suggested an involvement of D2-dopaminergic function in the expression of suicidal behavior by demonstrating a smaller growth hormone (GH) response to apomorphine, a dopaminergic agonist, in depressed patients with a history of suicide attempts in comparison to non-attempters. In the present study, in order to test this hypothesis, GH responses to intravenous apomorphine were measured in non-depressed patients with a history of suicide attempts. The study was performed in 17 non-depressed male patients with a score less than 12 on the 17-item HAMD. The patients were subgrouped into suicide attempters (N = 7) and non-attempters (N = 10). Mean GH peak responses to apomorphine differed significantly between suicide attempters and non-attempters: (mean ± SD) for GH peak, 10.4 ± 8.2 ng/mL vs 27.3 ± 13.1 ng/ml, F = 9.0, P = 0.009. In conclusion, dopaminergic disturbances seem to play a role in the biology of inward-directed aggression in non-depressed patients.

Keywords

depressiondopaminemonoaminesuicide
Type
Short Communications
Information
European Psychiatry , Volume 16 , Issue 7 , November 2001 , pp. 424 - 427
Copyright
Copyright © European Psychiatric Association 2001

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References

Agren, H.Life at risk: markers of suicidality in depression. Psychiat Dev 1983; 1: 87–104.Google ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd. ed. rev. Washington DC: APA; 1987.Google Scholar
Ansseau, MScheyvaerts, MDoumont, APoirrier, RLegros, JJFranck, G.Concurrent use of REM latency, dexamethasone suppression, clonidine and apomorphine tests as biological markers of endogenous depression. Psychiatry Res 1984; 12: 261–72.CrossRefGoogle ScholarPubMed
Arranz, BBlennow, KEriksson, AMansson, JEMarcusson, J.Serotonergic, noradrenergic, and dopaminergic measures in suicide brains. Biol Psychiatry 1997; 41: 1000–9.CrossRefGoogle ScholarPubMed
Beskow, JGottfries, CRoos, BWinblad, B.Determination of monoamine and monoamine metabolites in the human brain: postmortem studies in a group of suicides and in a control group. Acta Psychiatr Scand 1976; 53: 7–20.CrossRefGoogle Scholar
Bowden, CCheetham, SCLowther, SKatona, CLECrompton, MRHorton, RW.Reduced dopamine turnover in the basal ganglia of depressed suicides. Brain Res 1997; 769: 135–40.CrossRefGoogle ScholarPubMed
Crow, TJCross, AJCooper, SJ. et al. Neurotransmitter receptors and monoamine metabolites in the brains of patients with alzheimer-type dementia and depression and suicides. Neuropsychopharmacology 1984; 23: 1561–9.Google ScholarPubMed
Engström, GAlling, CBlennow, KRegnéll, GTräskman-Bendz, L.Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls. Eur Neuropsychopharmacol 1999; 9: 399–405.CrossRefGoogle ScholarPubMed
Franchimont, P.Le dosage radioimmunologique de l'hormone de croissance humaine. Cah Med Lyon 1968; 44: 887–98.Google Scholar
Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiat 1960; 23: 56–62.CrossRefGoogle ScholarPubMed
Laakmann, G.Psychopharmacology and depression research. Berlin: Springer-Verlag; 1990.CrossRefGoogle Scholar
Mann, JJMalone, KM.Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 1997; 41: 162–71.CrossRefGoogle ScholarPubMed
Montgomery, SAMontgomery, D.Pharmacological prevention of suicidal behavior. J Affective Disord 1982; 4: 291–8.CrossRefGoogle Scholar
Ohmori, TArora, RCMeltzer, HY.Serotonergic measures in suicide brain: the concentration of 5-HIAA, HVA, and tryptophan in frontal cortex of suicide victims. Biol Psychiatry 1992; 32: 57–71.CrossRefGoogle ScholarPubMed
Pitchot, WHansenne, Gonzalez Moreno, AAnsseau, M.Suicidal behavior and growth hormone response to apomorphine test. Biol Psychiatry 1992; 31: 1213–9.CrossRefGoogle ScholarPubMed
Pitchot, WGonzalez Moreno, AHansenne, MAnsseau, M.Growth hormone response to clonidine in nondepressed patients with a history of suicide attempts. Biol Psychiatry 1995; 37: 201–3.CrossRefGoogle Scholar
Pitchot, WHansenne, MGonzalez Moreno, AAnsseau, M.Effect of previous antidepressant therapy on the growth hormone response to apomorphine. Neuropsychobiology 1995; 32: 19–22.CrossRefGoogle ScholarPubMed
Pitchot, WReggers, JPinto, EHansenne, Fuchs, SPirard, S. et al. Reduced dopaminergic activity in depressed suicides. Psychoneuroendocrinology 2001; 26: 331–3.CrossRefGoogle ScholarPubMed
Roy, AAgren, APickar, DLinnoila, MDoran, ACutler, N. et al. Reduced CSF concentrations of homovanillic acid and homovanillic acid to 5-hydroxyindolacetic acid ratios in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. Am J Psychiatry 1986; 143: 1539–45.Google Scholar
Roy, ADe Jong, JLinnoila, M.Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients: a 5-years follow-up study. Arch Gen Psychiatry 1989; 46: 609–12.CrossRefGoogle Scholar
Roy, AKaroum, FPollack, S.Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide. Arch Gen Psychiatry 1992; 49: 447–50.CrossRefGoogle ScholarPubMed
Roy, APollack, S.Are cerebrospinal fluid or urinary monoamine metabolite measures stronger correlates of suicidal behavior in depression?. Neuropsychobiology 1994; 29: 164–7.CrossRefGoogle ScholarPubMed
Träskman, LAsberg, MBertilsson, LSjöstrand, L.Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 1981; 38: 631–6.CrossRefGoogle ScholarPubMed
Träskman-Bendz, LAlling, CAlsén, MRegnéll, GSimonsson, PÖhman, R.The role of monoamines in suicidal behavior. Acta Psychiatr Scand 371(Suppl)1993 45–47.CrossRefGoogle ScholarPubMed
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