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The risk of depressive symptoms in offspring exposed to prenatal alcohol and tobacco use: evidence from a population-based longitudinal study

Published online by Cambridge University Press:  01 September 2022

B. Duko ,
G. Pereira ,
K. Betts ,
R. Tait ,
J. Newnham  and
R. Alati
B. Duko*
Affiliation:
Curtin University, Curtin School Of Population Health, Perth, Australia
G. Pereira
Affiliation:
Curtin University, Curtin School Of Population Health, Perth, Australia
K. Betts
Affiliation:
Curtin University, Curtin School Of Population Health, Perth, Australia
R. Tait
Affiliation:
Curtin University, National Drug Research Institute (ndri), Perth, Australia
J. Newnham
Affiliation:
The University of Western Australia, Division Of Obstetrics And Gynecology, Faculty Of Health And Medical Sciences, Perth, Australia
R. Alati
Affiliation:
Curtin University, Curtin School Of Population Health, Perth, Australia
*
*Corresponding author.

Abstract

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Introduction

Evidence from epidemiological studies indicated that intrauterine exposure to alcohol and tobacco is linked with a number of adverse outcomes in offspring. However, few studies have linked prenatal alcohol and tobacco exposures to offspring depressive symptoms with mixed results.

Objectives

The objective of this study was to examine the link between maternal prenatal alcohol and tobacco exposures and depressive symptoms in offspring.

Methods

Using data from the Raine Study, a prospective multigenerational observational study, we examined the associations between maternal prenatal alcohol and tobacco use and the risk of depressive symptoms in offspring at age 17 years (N=1168). Depressive symptoms in offspring were measured using the Beck Depression Inventory for Youth. Log-binomial regression was used to estimate relative risk (RR) for associations between exposures and outcome. To better investigate the role of potential confounders, risk factors were sequentially added as adjustment variables in separate models.

Results

After adjustment for potential confounders, depressive symptoms in offspring remained related to maternal alcohol use of six or more standard drinks per week during the first trimester of pregnancy [RR 1.59 (95% CI: 1.11-2.26)]. Further, the risk of depressive symptoms was 50% higher for offspring exposed to prenatal tobacco use when compared to non-exposed. The Associations did not appear to be mediated by the effects of prenatal alcohol and tobacco use on adverse pregnancy outcomes.

Conclusions

Early screening and prevention of these exposures could possibly reduce depressive symptoms in offspring. Moreover, future examinations such as Mendelian Randomization that allow a stronger causal inference is warranted.

Disclosure

No significant relationships.

Keywords

tobaccooffspringalcoholdepressive symptoms
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S259
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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