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Resting-state fMRI markers of conversion to dementia in amnestic MCI: a pilot study

Published online by Cambridge University Press:  19 July 2023

E. Abdullina ,
Y. Panikratova ,
E. Ponomareva ,
I. Roshchina ,
N. Selezneva ,
I. Lebedeva  and
S. Gavrilova
E. Abdullina*
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
Y. Panikratova
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
E. Ponomareva
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
I. Roshchina
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
N. Selezneva
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
I. Lebedeva
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
S. Gavrilova
Affiliation:
Mental Health Research Center, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Patients with amnestic mild cognitive impairment (aMCI) have a high risk of transition to Alzheimer’s disease. Analysis of potential biomarkers of conversion to dementia in this clinical group is crucial for prognosis and early intervention.

Objectives

The aim of the pilot study was to compare whole-brain functioning characteristics (fMRI, spontaneous activity and local coherence) in aMCI converters and non-converters to dementia.

Methods

Nine aMCI converters to dementia of the Alzheimer’s type (mean age 69.2 ± 8.2; 9 females) and ten aMCI non-converters (mean age 65.9 ± 6.1; 8 females) underwent resting-state fMRI (3T). All patients were followed up for three years. Baseline whole-brain amplitude of low-frequency fluctuations (ALFF) and local coherence (LCOR) were compared between groups (CONN-fMRI toolbox 19.с, https://web.conn-toolbox.org/; p < .001 voxelwise, p(FDR) < .05 clusterwise). Age was included in the analyses as a second-level covariate.

Results

As compared to non-converters, aMCI converters were characterized by higher ALFF and LCOR values in the cluster located in the frontal medial cortex and frontal pole bilaterally.

Conclusions

Frontal medial cortex and frontal pole are involved in a wide range of cognitive functions, including episodic memory and “hot” (motivational) executive control (Rolls. ProgNeurobiol 2022; 217; Friedman, Robbins. Neuropsychopharmacology 2022; 47(1) 72-89). Both increased and decreased LCOR/ALFF values in aMCI converters compared to non-converters were found, although in the other regions (Mondragón et al. Dement Geriatr Cogn Dis Extra 2021; 11(3) 235–249; Khatri, Kwon. Front Aging Neurosci. 2022; 14). It seems reasonable to clarify if the brain functional features revealed in our study are the markers of conversion to dementia in aMCI.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S173 - S174
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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