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Response-related fMRI of veridical and false recognition of words

Published online by Cambridge University Press:  16 April 2020

Reinhard Heun ,
Frank Jessen ,
Uwe Klose ,
Michael Erb ,
Dirk-Oliver Granath  and
Wolfgang Grodd
Reinhard Heun*
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Street 25, Venusberg, 53105Bonn, Germany
Frank Jessen
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Street 25, Venusberg, 53105Bonn, Germany
Uwe Klose
Affiliation:
Department of Neuroradiology, Section Experimental NMR of the CNS, University of Tübingen, 72026Tübingen, Germany
Michael Erb
Affiliation:
Department of Neuroradiology, Section Experimental NMR of the CNS, University of Tübingen, 72026Tübingen, Germany
Dirk-Oliver Granath
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Street 25, Venusberg, 53105Bonn, Germany
Wolfgang Grodd
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-Street 25, Venusberg, 53105Bonn, Germany
*
*Corresponding author. E-mail address:[email protected] (R. Heun).
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Abstract

Objectives. – Studies on the relation between local cerebral activation and retrieval success usually compared high and low performance conditions, and thus showed performance-related activation of different brain areas. Only a few studies directly compared signal intensities of different response categories during retrieval. During verbal recognition, we recently observed increased parieto-occipital activation related to false alarms. The present study intends to replicate and extend this observation by investigating common and differential activation by veridical and false recognition.

Methods. – Fifteen healthy volunteers performed a verbal recognition paradigm using 160 learned target and 160 new distracter words. The subjects had to indicate whether they had learned the word before or not. Echo-planar MRI of blood-oxygen-level-dependent signal changes was performed during this recognition task. Words were classified post hoc according to the subjects’ responses, i.e. hits, false alarms, correct rejections and misses. Response-related fMRI-analysis was used to compare activation associated with the subjects’ recognition success, i.e. signal intensities related to the presentation of words were compared by the above-mentioned four response types.

Results. – During recognition, all word categories showed increased bilateral activation of the inferior frontal gyrus, the inferior temporal gyrus, the occipital lobe and the brainstem in comparison with the control condition. Hits and false alarms activated several areas including the left medial and lateral parieto-occipital cortex in comparison with subjectively unknown items, i.e. correct rejections and misses. Hits showed more pronounced activation in the medial, false alarms in the lateral parts of the left parieto-occipital cortex.

Conclusions. – Veridical and false recognition show common as well as different areas of cerebral activation in the left parieto-occipital lobe: increased activation of the medial parietal cortex by hits may correspond to true recognition, increased activation of the parieto-occipital cortex by false alarms may correspond to familiarity decisions. Further studies are needed to investigate the reasons for false decisions in healthy subjects and patients with memory problems.

Keywords

ActivationMemoryEpisodic memoryVeridical recognitionFamiliarityParietal cortex
Type
Original article
Information
European Psychiatry , Volume 19 , Issue 1 , January 2004 , pp. 42 - 52
Copyright
Copyright © 2003 European Psychiatric Association

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References

Andreasen, NCO'Leary, DSArndt, SCizadlo, THurtig, RRezai, Ket al.Short-term and long-term verbal memory. A positron emission tomography study. Proceedings of the National Academy of Science USA 1995;92:5111–5.CrossRefGoogle ScholarPubMed
Baschek, ILBredenkamp, JOehrle, BWippich, W. Bestimmung der Bildhaftigkeit (I), Konkretheit (C) und der Bedeutungshaltigkeit (m’) von 800 Substantiven. Zeitschrift für experimentelle angewandte Psychologie 1977;24:353–96.Google Scholar
Bookheimer, SYZeffiro, TABlaxton, TGaillard, WTheodore, W. Regional cerebral blood flow during object naming and word reading. Human Brain Mapping 1995;3:93–106.CrossRefGoogle Scholar
Brewer, JBZhao, ZDesmond, JEGlover, GHGabrieli, JDE. Making memories: brain activity that predicts how well visual experience will be remembered. Science 1998;281:1185–7.CrossRefGoogle Scholar
Buckner, RLKoutstaal, WSchacter, DLDale, AMRotte, MRosen, BR. Functional-anatomic study of episodic retrieval. II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis. Neuroimage 1998;7:163–75.CrossRefGoogle ScholarPubMed
Buckner, RLKoutstaal, WSchacter, DLWagner, ADRosen, BR. Functional-anatomic study of episodic retrieval using fMRI. I. Retrieval effort versus retrieval success. Neuroimage 1998;7:151–62.Google Scholar
Busatto, GHoward, RJHa, YBrammer, MWright, IWoodruff, PWRet al.A functional magnetic resonance imaging study of episodic memory. Neuro Report 1997;8:2671–5.Google ScholarPubMed
Cabeza, RNyberg, L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience 2000;12:1–47.CrossRefGoogle ScholarPubMed
Fletcher, PCFrith, CDGrasby, PMShallice, TFrackowiak, RSJDolan, RJ. Brain systems for encoding and retrieval of auditory-verbal memory. An in vivo study in humans. Brain 1995;118:401–16.Google ScholarPubMed
Fletcher, PCFrith, CDRugg, MD. The functional neuroanatomy of episodic memory. Trends in Neuroscience 1997;20:213–8.CrossRefGoogle ScholarPubMed
Fletcher, PCShallice, TFrith, CDFrackowiak, RSJDolan, RJ. The functional roles of prefrontal cortex in episodic memory. II. Retrieval Brain 1998;121:1249–56.Google ScholarPubMed
Friston, KJ. Statistical parametric mapping and other analyses of functional imaging data. In: Toga, AWMazziotta, JC editors. Brain mapping. The methods. San Diego, NewYork: Academic Press; 1996. p.363–86.Google Scholar
Friston, KJJosephs, ORees, GTurner, R. Nonlinear event-related responses in fMRI. Magnetic Resonance in Medicine 1998;39:41–52.CrossRefGoogle ScholarPubMed
Gabrieli, JDEBrewer, JBDesmond, JEGlover, GH. Separate neural bases of 2 fundamental memory processes in the human medial-temporal lobe. Science 1997;276:264–6.CrossRefGoogle Scholar
Gonsalves, BPaller, KA. Neural events that underlie remembering something that never happened. Nature Neuroscience 1997:31316–21.Google Scholar
Grasby, PMFrith, CDFriston, KJBench, CFrackowiak, RSJDolan, RJ. Functional mapping of brain areas implicated in auditory—verbal memory function. Brain 1993;116:1–20.CrossRefGoogle ScholarPubMed
Grasby, PMFrith, CDFriston, KJSimpson, JFletcher, PCFrackowiak, RSJet al.A graded task approach to the functional mapping of brain areas implicated in auditory-verbal memory. Brain 1994;117:1271–82.CrossRefGoogle ScholarPubMed
Grill-Spector, KKushnir, KEdelman, TItzchak, SMalach, YR. Cueinvariant activation in object-related areas of the human occipital lobe. Neuron 1998;21:191–201.CrossRefGoogle ScholarPubMed
Grill-Spector, KKushnir, THendler, TMalach, R. The dynamics of object-selective activation correlate with recognition performance in humans. Nature Neuroscience 2000;3:837–43.CrossRefGoogle ScholarPubMed
Haxby, JVUngerleider, LGHorwitz, BMaisog, JMRapoport, SIGrady, CL. Face encoding and recognition in the human brain. Proceedings of the National Academy of Sciences USA 1996;93:922–7.CrossRefGoogle ScholarPubMed
Henson, RNARugg, MDJosephs, ODolan, RJ. Recollection and familiarity in recognition memory: an event-related functional magnetic resonance imaging study. The Journal of Neuroscience 1999;10:3962–72.CrossRefGoogle Scholar
Henson, RNARugg, MDShallice, TDolan, RJ. Confidence in recognition memory for words: dissociating right prefrontal roles in episodic retrieval. Journal of Cognitive Neuroscience 2000;12:913–23.CrossRefGoogle ScholarPubMed
Heun, RJessen, FKlose, UErb, MGranath, D-OGrodd, W. Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success. Psychiatry Research: Neuroimaging 2000;99:137–50.Google ScholarPubMed
Heun, RKlose, UJessen, FErb, MPapassotiropoulos, ALotze, Met al.Functional MRI of cerebral activation during encoding and retrieval of words. Human Brain Mapping 1999;8:157–69.3.0.CO;2-G>CrossRefGoogle Scholar
Hirano, SKojima, HNaito, YHonjo, I. Cortical speech processing mechanisms while vocalizing visually-presented languages. Neuroreport 1996;8:363–7.CrossRefGoogle ScholarPubMed
Iidaka, TSadato, N,Yamada, HYonekura, Y. Functional asymmetry of human prefrontal cortex in verbal and non-verbal episodic memory as revealed by fMRI. Cognitive Brain Research 2000;9:73–83.CrossRefGoogle ScholarPubMed
Jacoby, LL. A process dissociation framework: separating automatic from intentional uses of memory. Journal of Memory and Language 1991;30:513–41.CrossRefGoogle Scholar
Kanwisher, NMcDermott, JChun, MM. The fusiform face area: a module in human extrastriate cortex specialized for face perception. Journal of Neuroscience 1997;11:4302–11.CrossRefGoogle Scholar
Klose, UErb, MWildgruber, DMüller, EGrodd, W. Improvement of the acquisition of large amount of mr-images on a conventional whole body system. Magnetic Resonance Imaging 1999;17:471–4.CrossRefGoogle ScholarPubMed
Konishi, SWheeler, MEDonaldson, DIBuckner, RL. neural correlates of episodic retrievalo success. Neuro Image 2000;12:276–86.Google ScholarPubMed
Kopelman, MDStevens, TGFoli, SGrasby, P. PET activation of the medial temporal lobe in learning. Brain 1998;121:875–87.CrossRefGoogle Scholar
Le Bihan, DTurner, RZeffiro, TACuénod, CAJezzard, PBonnerot, V. Activation of human primary visual cortex during visual recall: a magnetic resonance imaging study. Proceedings of the National Academy of Science USA 1993;90:11802–5.Google ScholarPubMed
LeCompte, DC. Recollective experience in the revelation effect: separating the contributions of recollection and familiarity. Memory & Cognition 1995;23:324–34.Google ScholarPubMed
Lepage, MGhaffar, ONyberg, LTulving, E. Prefrontal cortex and episodic memory retrieval mode. Proceedings of the National Academy of Science USA 2000;97:506–11.CrossRefGoogle ScholarPubMed
Maguire, EAFrith, CDMorris, RGM. The functional neuroanatomy of comprehension and memory: the importance of prior knowledge. Brain 1999;122:1839–50.CrossRefGoogle ScholarPubMed
Maguire, EAMummery, CJ. Differential modulation of a common memory retrieval network revealed by positron emission tomography. Hippocampus 1999;9:54–61.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Malach, RReppas, JBBenson, RRKwong, KKJiang, HKennedy, WAet al.Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex. Proceedings of the National Academy of Science USA 1995;2:8135–9.CrossRefGoogle Scholar
Mark, RERugg, MD. Age effects on brain activity associated with episodic memory retrieval. An electrophysiological study. Brain 1998;121:861–73.CrossRefGoogle ScholarPubMed
Markowitsch, HJCalabrese, PFink, GRDurwen, HFKessler, JHärting, Cet al.Impaired episodic memory retrieval in a case of probable psychogenic amnesia. Psychiatry Research: Neuroimaging Section 1997;74:119–26.CrossRefGoogle Scholar
Mather, MHenkel, LAJohnson, MK. Evaluating characteristics of false memories: remember/know judgments and memory characteristics questionnaire compared. Memory & Cognition 1997;25:826–37.CrossRefGoogle ScholarPubMed
McIntosh, ARNyberg, LBookstein, FLTulving, E. Differential functional connectivity of prefrontal and medial temporal cortices during episodic memory retrieval. Human Brain Mapping 1997;5:323–7.3.0.CO;2-D>CrossRefGoogle ScholarPubMed
Norman, KASchacter, DL. False recognition in younger and older adults: exploring the characteristics of illusory memories. Memory & Cognition 1997;25:838–48.CrossRefGoogle ScholarPubMed
Nyberg, LMcIntosh, ARHoule, SNilsson, L-GTulving, E. Activation of medial temporal structures during episodic memory retrieval. Nature 1996;380:715–7.CrossRefGoogle ScholarPubMed
Ojemann, JGBuckner, RLCorbetta, MRaichle, ME. Imaging studies of memory and attention. Neurosurgery Clinics of North America 1997;8:307–19.CrossRefGoogle ScholarPubMed
Oldfield, RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97–113.CrossRefGoogle ScholarPubMed
Oldigs-Kerber, JAdamus, WSKitzinger, M. Zur Beeinflussung von verbalen Lernund Gedächtnisprozessen durch Anticholinergica am Beispiel von Scopolamin. Ein pharmakopsychologischer Beitrag für die neuropsychologische Praxis. Zeitschrift für Neuropsychologie 1991;2:29–40.Google Scholar
Osherson, DPerani, DCappa, SSchnur, TGrassi, FFazio, F. Distinct brain loci in deductive versus probabilistic reasoning. Neuropsychologia 1998;36:369–76.CrossRefGoogle ScholarPubMed
Otten, LJHenson, RNARugg, MD. Depth of processing effects on neural correlates of memory encoding. Relationship between findings from across-and within-task comparisons. Brain 2001;124:399–412.CrossRefGoogle Scholar
Perry, EWalker, MGrace, JPerry, R. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends in Neuroscience 1999;22:273–80.CrossRefGoogle Scholar
Petrides, M. Visuomotor conditional associative learning after frontal and temporal lesions in the human brain. Neuropsychologia 1997;35:989–97.CrossRefGoogle Scholar
Petrides, M. Specialized systems for the processing of mnemonic information within the primate frontal cortex. Philosophical Transactions of the Royal Society of London B 1996;351:1455–62.Google ScholarPubMed
Price, CJFriston, KJ. Cognitive conjunction: a new approach to brain activation experiments. Neuroimage 1997;5:261–70.CrossRefGoogle ScholarPubMed
Ragland, JDGur, RCLazarev, MGSmith, RJSchroeder, LRaz, Jet al.Hemispheric activation of anterior and inferior prefrontal cortex during verbal encoding and recognition: a PET study of healthy volunteers. Neuro Image 2000;11:624–33.Google ScholarPubMed
Riddle, WO’Carroll, REDougall, NVan Beck, MMurray, CCurran, SMet al.A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia. British Journal of Psychiatry 1993;163:166–72.CrossRefGoogle ScholarPubMed
Rosen, BRBuckner, RLDale, AM. Event-related functional MRI: past, present, and future. Proceedings of the National Academy of Science USA 1998;95:773–80.CrossRefGoogle ScholarPubMed
Rugg, MDFletcher, PCFrith, CDFrackowiak, RSJDolan, RJ. Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval. Brain 1996;119:2073–83.CrossRefGoogle ScholarPubMed
Sakurai, YMomose, TIwata, MWatanabe, T. Semantic process in kana word reading: activation studies with positron emission tomography. Neuroreport 1993;4:327–30.CrossRefGoogle ScholarPubMed
Saykin, AJJohnson, SCFlashman, LAMcAllister, TWSparling, MDarcey, TMet al.Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: an fMRI study. Brain 1999;122:1963–71.CrossRefGoogle Scholar
Schacter, DL. Illusory memories: a cognitive neuroscience analysis. Proceedings of the National Academy of Science USA 1996;93:13527–33.Google ScholarPubMed
Schacter, DLAlpert, NMSavage, CRRauch, SLAlberts, MS. Conscious recollection and the human hippocampal formation: evidence from positron emission tomography. Proceedings of the National Academy of Science USA 1996;3:321–5.CrossRefGoogle Scholar
Schacter, DLBuckner, RLKoutstaal, WDale, AMRosen, BR. Late onset of anterior prefrontal activity during true and false recognition: an event-related fMRI study. Neuroimage 1997;6:259–69.CrossRefGoogle ScholarPubMed
Schacter, DLKoutstaal, WJohnson, MKGross, MSAngell, KE. False recollection induced by photographs: a comparison of older and younger adults. Psychology and Aging 1997;12:203–15.CrossRefGoogle ScholarPubMed
Schacter, DLReiman, ECurran, TYun, LSBandy, DMcDermott, KBet al.Neuroanatomical correlates of veridical and illusory recognition memory: evidence from positron emission tomography. Neuron 1996;17:267–74.CrossRefGoogle ScholarPubMed
Schacter, DLReiman, EUecker, APolster, MRYun, LSCooper, AL. Brain regions associated with retrieval of structurally coherent visual information. Nature 1995;376:587–90.CrossRefGoogle ScholarPubMed
Sewards, TVSewards, MA. Visual awareness due to neuronal activities in subcortical structures: a proposal. Consciousness and Cognition 2000;9:86–116.CrossRefGoogle ScholarPubMed
Shallice, TFletcher, PFrith, CDGrasby, PFrackowiak, RSJDolan, RJ. Brain regions associated with acquisition and retrieval of verbal episodic memory. Nature 1994;368:633–5.CrossRefGoogle ScholarPubMed
Stark, CELSquire, LR. fMRI activity in the medial temporal lobe during recognition memory as a function of study-test interval. Hippocampus 2000;10:329–37.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Stark, CELSquire, LR. Functional magnetic resonance imaging (fMRI) activity in the hippocampal region during recognition memory. The Journal of Neuroscience 2000;20:7776–81b.CrossRefGoogle ScholarPubMed
Tulving, EHabib, RNyberg, LLepage, MMcIntosh, AR. Positron emission tomography correlations in and beyond medial temporal lobes. Hippocampus 1999;9:71–82.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Tulving, EKapur, SMarkowitsch, HJCraik, FIMHabib, RHoule, S. Neuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition. Proceedings of the National Academy of Science 1994;91:2012–5.CrossRefGoogle ScholarPubMed
Tulving, EMarkowitsch, HJCraik, FIMHabib, RHoule, S. Novelty and familiarity activations in PET studies of memory encoding and retrieval. Cerebral Cortex 1996;6:71–9.CrossRefGoogle ScholarPubMed
Wagner, ADSchacter, DLRotte, MKoutstaal, WMaril, ADale, AMet al.Building memories: remembering and forgetting of verbal experiences as predicted by brain activity. Science 1998;281:1188–91.CrossRefGoogle ScholarPubMed
Warburton, EWise, RJSPrice, CJWeiller, CHadar, URamsay, SFrackowiak, RSJ. Noun and verb retrieval by normal subjects. Studies with PET. Brain 1996;119:159–79.Google ScholarPubMed
Yonelinas, APJacoby, LL. Noncriterial recollection: familiarity as automatic, irrelevant recollection. Consciousness and Cognition 1996;5:131–41.CrossRefGoogle ScholarPubMed
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