Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-25T08:31:10.421Z Has data issue: false hasContentIssue false
  • English
  • Français

The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder

Published online by Cambridge University Press:  16 April 2020

T. Christodoulou ,
M. Lewis ,
G.B. Ploubidis  and
S. Frangou
T. Christodoulou
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
M. Lewis
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
G.B. Ploubidis
Affiliation:
Department of Psychiatry, University of Cambridge, UK
S. Frangou*
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
*
*Corresponding author. E-mail address: [email protected] (S. Frangou).
Get access

Abstract

Background

Impulsivity, a core feature of bipolar disorder (BD), is a multifaceted concept encompassing failure of response inhibition and poor decision-making. Abnormalities in these two cognitive domains have been reported in BD patients but their relationship with impulsivity has not been explored.

Methods

Twenty-five remitted patients with BD completed the Barratt Impulsiveness Scale (BIS) and performed the Hayling Sentence Completion Task (HSCT) and a computerized version of the Iowa Gambling task. The HSCT total errors scaled score was used as a measure of response inhibition while the gabling task score, which reflects participants' ability to make advantageous choices, was used a measure of decision making.

Results

Higher scores on the BIS attentional and non-planning subscales were respectively associated with more errors in the HSCT and less advantageous choices in the gambling task.

Limitations

All patients were medicated. Healthy participants were not included.

Conclusions

Viewed in the context of recent relevant studies our findings suggest that impulsivity, response inhibition and decision-making in BD may represent behavioural manifestations of the same underlying biological mechanism possibly linked to ventral prefrontal cortical function.

Keywords

Bipolar disorderImpulsivityResponse inhibitionDecision making
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 4 , June 2006 , pp. 270 - 273
Copyright
Copyright © European Psychiatric Association 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Fourth Edition (DSM-IV). Washington, DC: APA; 1994.Google Scholar
Bechara, A, Damasio, H, Tranel, D, Anderson, SWDissociation of working memory from decision making within the human prefrontal cortex. J. Neurosci. 1998;18:428–437.CrossRefGoogle ScholarPubMed
Blumberg, HP, Leung, HC, Skudlarski, P, Lacadie, CM, Fredericks, CA, Harris, BCet al.A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch. Gen. Psychiatry 2003;60:601–609.10.1001/archpsyc.60.6.601CrossRefGoogle ScholarPubMed
Burgess, PW, Shallice, TThe Hayling and Brixton tests. Bury St Edmunds: Thames Valley Test Company; 1997.Google Scholar
Collette, F, Van der Linden, M, Delfiore, G, Degueldre, C, Luxen, A, Salmon, EThe functional anatomy of inhibition processes investigated using the Hayling task. Neuroimaging 2001;14:258–267.CrossRefGoogle ScholarPubMed
Corruble, E, Damy, C, Guelfi, JDImpulsivity: a relevant dimension in depression regarding suicide attempts?. J. Affect. Disord. 1999;53:211–215.CrossRefGoogle ScholarPubMed
Dias, R, Robbins, TW, Roberts, ACDissociation in prefrontal cortex of affective and attentional shifts. Nature 1996;380:69–72.CrossRefGoogle ScholarPubMed
Dougherty, DM, Mathias, CW, Marsh, DM, Papageorgiou, TD, Swann, AC, Moeller, FGLaboratory measured behavioral impulsivity relates to suicide attempt history. Suicide Life Threat. Behav. 2004;34:374–385.CrossRefGoogle ScholarPubMed
Evenden, JLVarieties of impulsivity. Psychopharmacology (Berl.) 1999;146:348–361.10.1007/PL00005481CrossRefGoogle ScholarPubMed
Eysenck, S, Eysenck, HThe place of impulsiveness in a dimensional description of personality description. Br. J. Psychol. 1977;16:57–68.Google Scholar
First, M, Spitzer, R, Gibbon, M, Williams, JStructured clinical interview for DSM-IV Axis 1 disorders. New York, NY: New York State Psychiatric Institute, Biometrics Research Department; 1996.Google Scholar
Frangou, S, Donaldson, S, Hadjulis, M, Landau, S, Goldstein, LHThe Maudsley Bipolar Disorder Project: Executive Dysfunction in Bipolar Disorder I and its Clinical Correlates. Biol. Psychiatry. 2005;58:859–864.10.1016/j.biopsych.2005.04.056CrossRefGoogle ScholarPubMed
Frangou, S, Raymont, V, Kingston, J, Shergill, SSInvestigating the functional interface between dorsal and ventral prefrontal circuitry in bipolar disorder. Bipolar Disord. 2003;5:s47–s48.Google Scholar
Frosch, J, Wortis, SBA contribution to the nosology of the impulse disorders. Am. J. Psychiatry 1954;111:132–137.CrossRefGoogle ScholarPubMed
Horn, NR, Dolan, R, Elliott, R, Deakin, J.F.W., Woodruff, P.W.R.Response inhibition and impulsivity: an fMRI study. Neuropsychologia 2003;41:1959–1966.CrossRefGoogle ScholarPubMed
Moeller, FG, Barratt, ES, Dougherty, DM, Schmitz, JM, Swann, ACPsychiatric aspects of impulsivity. Am. J. Psychiatry 2001;158:1783–1793.CrossRefGoogle ScholarPubMed
Monroe, RREpisodic behavioral disorders: a psychodynamic and neurophysiologic analysis. Cambridge, MA: Harvard University Press; 1970.Google Scholar
Montgomery, S, Asberg, MA new depression scale designed to be sensitive to change. Br. J. Psychiatry 1979;134:382–389.CrossRefGoogle ScholarPubMed
Murphy, FC, Rubinsztein, JS, Michael, A, Rogers, RD, Robbins, TW, Paykel, ESet al.Decision-making cognition in mania and depression. Psychol. Med. 2001;31:679–693.CrossRefGoogle ScholarPubMed
Nathaniel-James, DA, Fletcher, P, Frith, CDThe functional anatomy of verbal initiation and suppression using the Hayling test. Neuropsychologia 1997;35:559–566.CrossRefGoogle ScholarPubMed
Norman, DA, Shallice, TAttention to action: willed and automatic control behavior. Center for human information processing report No. 99. Berkley: University of California Press; 1980.Google Scholar
Patton, J, Standford, M, Barratt, EFactor Structure of the Barratt Impulsiveness Scale. J. Clin. Psychol. 1995;51:768–774.10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-13.0.CO;2-1>CrossRefGoogle ScholarPubMed
Quraishi, S, Frangou, SNeuropsychology of bipolar disorder: a review. J. Affect. Disord. 2002;72:209–226.CrossRefGoogle ScholarPubMed
Rubinsztein, JS, Michael, A, Paykel, ES, Sahakian, BJCognitive impairment in remission in bipolar affective disorder. Psych. Med. 2000;30:1015–1036.CrossRefGoogle ScholarPubMed
Swann, AC, Pazzaglia, P, Nicholls, A, Dougherty, DM, Moeller, FGImpulsivity and phase of illness in bipolar disorder. J. Affect. Disord. 2003;73:105–111.CrossRefGoogle ScholarPubMed
Swann, AC, Dougherty, DM, Pazzaglia, PJ, Pham, M, Moeller, FGImpulsivity: a link between bipolar disorder and substance abuse. Bipolar Disord. 2004;6:204–212.CrossRefGoogle ScholarPubMed
Swann, AC, Birnbaum, D, Jagar, AA, Dougherty, DM, Moeller, FGAcute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol. Psychiatry 2005;57:1209–1211.10.1016/j.biopsych.2005.02.007CrossRefGoogle ScholarPubMed
Young, R, Biggs, J, Zieglar, V, Meyer, DA rating scale for mania: reliability, validity sensitivity. Br. J. Psychiatry 1978;133:429–435.CrossRefGoogle Scholar
Zimmerman, M, Chelminski, I, Posternak, MA review of Studies of the Montgomery–Asberg Depression Rating Scale in controls: implications for the definition of remission in treatment studies of depression. Int. Clin. Psychopharmacol. 2004;19:1–7.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.