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PW01-214 - Long-Term Outcomes In Patients With First Psychotic Episode And Cannabis Use

Published online by Cambridge University Press:  17 April 2020

S. Alberich
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
S. Barbeito
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
M. Fernández
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
M. Karim Haidar
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
S. Ron
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
A. Villamor
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
A. Jimeno
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
I. Zorrilla
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
L. Celaya
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain
M.A. Alecha
Affiliation:
Biobanco, Santiago Apostol Hospital, Vitoria, Spain
A. González-Pinto
Affiliation:
Psychiatry, Santiago Apostol Hospital, Vitoria, Spain

Abstract

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Objectives

To evaluate the influence of cannabis in the long-term follow-up in patients with a first psychotic episode, comparing those who have never used cannabis with (a) those who used cannabis before the first psychotic episode but stopped it during the follow-up, and (b) those who used cannabis both before and after the first psychotic episode.

Method

Patients were followed from the first psychotic admission. They were assessed at 1, 3 and 5 years obtaining information about functional outcome, positive and negative symptoms. At 8th year functional outcome was evaluated. Patients were classified in 3 groups: 40 that never used cannabis (NU), 27 that used cannabis and stopped during follow-up (CUS), and 25 that had continued use during follow-up (CU).

Results

At baseline, there were differences neither in functional outcome nor in negative symptoms. The CUS group improved the functional outcome during the follow-up (p< 0.001), while CU and NU groups did not show any significant results (p= 0.466 and p= 0.370 respectively). CUS group had also a significant decreasing trend in negative symptoms (p= 0.012), whereas for the other two groups no significant results were observed (p= 0.069 and p= 0.226 respectively). All groups improved in positive symptoms during follow-up.

Conclusions

Although cannabis use has deleterious effect, to stop it after the first psychotic episode produces a clearly improvement in the long-term follow-up.

Type
Substance related disorders
Copyright
Copyright © European Psychiatric Association 2009
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