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Psychotherapy employed additionally to Psychopharmacotherapy is not related to Better Treatment Outcome in Major Depressive Disorder

Published online by Cambridge University Press:  01 September 2022

L. Bartova ,
G. Fugger ,
M. Dold ,
M. Mitschek ,
J. Zohar ,
J. Mendlewicz ,
D. Souery ,
S. Montgomery ,
C. Fabbri  and
A. Serretti
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L. Bartova*
Affiliation:
Medical University of Vienna, Department Of Psychiatry And Psychotherapy, Vienna, Austria
G. Fugger
Affiliation:
Medical University of Vienna, Department Of Psychiatry And Psychotherapy, Vienna, Austria
M. Dold
Affiliation:
Medical University of Vienna, Department Of Psychiatry And Psychotherapy, Vienna, Austria
M. Mitschek
Affiliation:
Medical University of Vienna, Department Of Psychiatry And Psychotherapy, Vienna, Austria
J. Zohar
Affiliation:
Chaim Sheba Medical Center, Psychiatric Division, Tel Hashomer, Israel
J. Mendlewicz
Affiliation:
Free University of Brussels, School Of Medicine, Brussels, Belgium
D. Souery
Affiliation:
Psy Pluriel, Centre Européen De Psychologie Médicale, Brussels, Belgium
S. Montgomery
Affiliation:
University of London, Imperial College School Of Medicine, London, United Kingdom
C. Fabbri
Affiliation:
University of Bologna, Department Of Biomedical And Neuromotor Sciences, Bologna, Italy
A. Serretti
Affiliation:
University of Bologna, Department Of Biomedical And Neuromotor Sciences, Bologna, Italy
S. Kasper
Affiliation:
Medical University of Vienna, Department Of Psychiatry And Psychotherapy, Vienna, Austria
*
*Corresponding author.

Abstract

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Introduction

Although numerous effective antidepressant (AD) strategies are available for the treatment of major depressive disorder (MDD), many patients do not achieve satisfactory treatment response.

Objectives

The aims of the present European, cross-sectional, multicenter, naturalistic study were (1) to determine the proportion of patients suffering from primary MDD who received additional psychotherapy to their ongoing psychopharmacotherapy and (2) to identify the associated socio-demographic and clinical patterns.

Methods

Patients receiving both treatments were compared to those lacking concomitant additional psychotherapy that was manual-driven psychotherapy (MDP) in all cases.

Results

While 68.8% of a total of 1279 MDD patients received exclusively psychopharmacotherapy, 31.2% underwent a psychopharmacotherapy-MDP combination. The latter patient population was rather younger, higher educated, employed, exhibited an earlier mean age of MDD onset, lower severity of current depressive symptoms with lower odds of suicidality and higher rates of melancholic features, and comorbid asthma and migraine, and was generally treated with lower daily doses of their first-line ADs. Whereas agomelatine was more commonly dispensed in these patients, selective serotonin reuptake inhibitors were more often prescribed in MDD patients lacking additional MDP. No significant between-group differences were detected in terms of treatment outcome.

Conclusions

The fact that the employment of additional MDP was not related to better treatment outcome in MDD represents our major and clinically most relevant finding. Generally, MDP was employed in a minority of our patients who experienced rather beneficial socio-demographic and clinical characteristics. This might reflect an inferior accessibility of these psychotherapeutic techniques for patients who are more severely ill and less socio-economically privileged.

Disclosure

References Bartova L, Fugger G, Dold M, Swoboda MMM, Zohar J, Mendlewicz J, Souery D, Montgomery S, Fabbri C, Serretti A, Kasper S. Combining psychopharmacotherapy and psychotherapy is not associated with better treatment outcome in major depressive disor

Keywords

antidepressant treatmentPsychotherapyPsychopharmacotherapymajor depressive disorder
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S73 - S74
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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