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Psychopathology measured by established self-rating scales and correlated to serotonin measures in patients with fibromyalgia

Published online by Cambridge University Press:  16 April 2020

NJ Krag ,
J Nørregaard ,
I Hindberg ,
JK Larsen  and
B Danneskiold-Samsøe
NJ Krag*
Affiliation:
Departments of Psychiatry, Rheumatology and Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark
J Nørregaard
Affiliation:
Departments of Psychiatry, Rheumatology and Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark
I Hindberg
Affiliation:
Departments of Psychiatry, Rheumatology and Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark
JK Larsen
Affiliation:
Departments of Psychiatry, Rheumatology and Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark
B Danneskiold-Samsøe
Affiliation:
Departments of Psychiatry, Rheumatology and Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark
*
*Correspondence and reprints: Dr NJ Krag, Søbredden 36F, 2820 Gentofte, Denmark.
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Summary

The objective of the study was to evaluate the presence of psychopathology in fibromyalgia patients compared to a control group of rheumatic patients with pain. Forty-nine fibromyalgia patients and 33 controls were evaluated using established self-rating scales. Serotonin was determined using a radioenzymatic method. Fibromyalgia patients scored significantly higher than the controls on the majority of the subscales on the SCL-90, the two subscales on the Spielberger State and Trait Anxiety Inventory, the GHQ 12 scale and on a visual analogue pain scale. In a multivariate analysis the somatization dimension followed by the state anxiety accounted for the highest difference. Platelet-poor plasma serotonin, platelet serotonin and platelet uptake index were not significantly different between the groups. In conclusion, fibromyalgia patients presented quantitatively more psychopathology than the control group on a wide range of psychopathologic axes, and this cannot solely be accounted for by their higher level of pain.

Keywords

fibromyalgiaself-rating scalespsychiatrydepressionanxietypain-evaluation scalesserotonin
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 404 - 409
Copyright
Copyright © Elsevier, Paris 1995

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