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Psychiatric Co-morbidities in a French Cohort of Adults with High-functioning Autism (HFA)

Published online by Cambridge University Press:  23 March 2020

A. Gaman ,
O. Godin ,
I. Scheid ,
D. Monnet ,
E. Murzi ,
A. Martinez Teruel ,
F. Amsellem ,
H. Laouamri ,
K. Souyris  and
J. Houneou
...Show all authors
A. Gaman
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Inserm, U955 Translational Psychiatry, Paris, France Fondation Fondamental, Centre Expert Asperger, Paris, France
O. Godin
Affiliation:
Fondation Fondamental, Informatics and Data Base, Paris, France
I. Scheid
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Fondation Fondamental, Centre Expert Asperger, Paris, France
D. Monnet
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Fondation Fondamental, Centre Expert Asperger, Paris, France
E. Murzi
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Fondation Fondamental, Centre Expert Asperger, Paris, France
A. Martinez Teruel
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Fondation Fondamental, Centre Expert Asperger, Paris, France
F. Amsellem
Affiliation:
Inserm, U955 Translational Psychiatry, Paris, France Institute Pasteur, Human Genetics and Cognitive Studies, Paris, France Hôpital “Robert Debré”, Child and Adolescent Psychiatry, Paris, France
H. Laouamri
Affiliation:
Fondation Fondamental, Informatics and Data Base, Paris, France
K. Souyris
Affiliation:
Fondation Fondamental, Informatics and Data Base, Paris, France
J. Houneou
Affiliation:
Inserm, U955 Translational Psychiatry, Paris, France Fondation Fondamental, Centre Expert Asperger, Paris, France Neurospin, Uniact Psychiatry Team, Paris, France
T. Infor
Affiliation:
Roche, Cooperative Group, Basel, France
R. Delorme
Affiliation:
Inserm, U955 Translational Psychiatry, Paris, France Institute Pasteur, Human Genetics and Cognitive Studies, Paris, France Hôpital “Robert Debré”, Child and Adolescent Psychiatry, Paris, France
M. Leboyer
Affiliation:
Hopital Albert Chenevier AP–HP, Psychiatry, Créteil, France Inserm, U955 Translational Psychiatry, Paris, France Fondation Fondamental, Centre Expert Asperger, Paris, France

Abstract

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Background and rationale

Psychiatric comorbidities are shown to be very prevalent in patients diagnosed with Autism Spectrum Disorder (ASD), up high to 53% for mood, 50% anxiety and 43% for ADHD disorders in an European cohort of adults with HFA. Using a new approach, our study proposes to explore aspects of comorbidities in the largest French cohort of HFA adults (C0733/InfoR) by implying qualitative and quantitative clinical tools.

Aims

To explore: (1) the prevalence rates of psychiatric comorbidities; (2) the interplay between comorbidities and the ASD symptoms.

Methods

Diagnosis was made according to DSM 5 criteria. Dimensional evaluation used Social Responsiveness Scale (SRS), Systemizing Quotient (SQ) and Empathy Quotient (EQ). We used T-test, Mann–Whitney test and linear regression models.

Results

We included 103 patients (mean age 29.3, sex ratio M/F: 3.4:1). Lifetime prevalence rates of 53.5% for depressive disorder 73.5% for anxiety disorders and 37.5% for ADHD were found. Subjects with psychotic co-morbid symptoms had a more severe social deficit (SRS score 66.2 vs 77.9 P < 0.05); patients with ADHD, lower cognition (mean IQ total 107.7 vs 99.0 P < 0.05). SQs (P < 0.05) were significantly higher in patients with co-morbid psychosis, dysthymia, suicide attempts, and depressive disorders and directly correlated with age (β = 0.35, P < 0.05). SQ and EQ were inversely correlated.

Discussion

The results reproduce the high prevalence of comorbidities in other studies and explore its association with social functioning and cognition. Identification of associated psychiatric conditions in subjects with HFA is therefore a crucial clinical issue potentially guiding the treatment.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Co-morbidity/dual pathologies and guidelines/Guidance – part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S136
Copyright
Copyright © European Psychiatric Association 2017
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