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Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats

Published online by Cambridge University Press:  13 August 2021

J. Jovanovic Mirkovic ,
C. Alexopoulos ,
Z. Jurinjak ,
M. Jerkan  and
N. Medojevic
J. Jovanovic Mirkovic
Affiliation:
Health Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, Serbia
C. Alexopoulos
Affiliation:
Health Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, Serbia
Z. Jurinjak*
Affiliation:
Health Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, Serbia
M. Jerkan
Affiliation:
Physicals Medicine, Health center Nis, nis, Serbia
N. Medojevic
Affiliation:
Urology, Clinical Center Nis, nis, Serbia
*
*Corresponding author.

Abstract

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Introduction

Acute and chronic exposure to cadmium (Cd), due to its increased use and application in the industry, can result in the development of atherosclerosis, the occurrence of cardiomyopathy, cerebrovascular stroke, as well as carcinogenesis in some organs. The target for cadmium action is thought to be the vascular endothelium.

Objectives

The aim of this study is to investigate the occurrence of oxidative stress on blood vessel endothelium induced by subacute administration of cadmium, as well as the protective power of alpha-lipoic acid (α-LA) supplementation on the Wistar strain albino rat model system.

Methods

After anesthesia of rats in the vivarium of the Scientific Research Center for Biomedicine, Faculty of Medicine in Niš, blood was collected by cardiac puncture and sent to the Clinic of Nephrology, Clinical Center in Niš, Serbia for determination of hematological parameters.

Results

According to the results of this study, it can be seen that the number of granulocytes is reduced due to cadmium intoxication, which is probably induced by the migration of neutrophils into tissues. The number of lymphocytes was increased due to subacute cadmium intoxication compared to the control group of animals. The positive efficacy of α-LA supplements in combating the adverse effects of cadmium on blood vessels is also confirmed.

Conclusions

Cadmium administration is thought to cause a systemic inflammatory reaction due to the formation of free radicals in the blood vessel endothelium. Administration of α-LA supplement confirms that it can be used as an antioxidant in the clinical management of many diseases and also in cadmium intoxication.

Disclosure

No significant relationships.

Keywords

cadmiumblood vesselantioxidantoxidative stressalpha-lipoic acid
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S719
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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