Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-27T19:23:12.318Z Has data issue: false hasContentIssue false
  • English
  • Français

Premorbid adjustment in persons at high risk for psychosis

Published online by Cambridge University Press:  16 April 2020

R.K. Salokangas ,
M. Heinimaa ,
J. Klosterkoetter ,
S. Ruhrman ,
H. Graf von Reventlow ,
D. Linszen ,
P. Dingemans ,
M. Birchwood  and
P. Patterson
R.K. Salokangas
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland Turku University Central Hospital, Turku, Finland
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
J. Klosterkoetter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
S. Ruhrman
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
H. Graf von Reventlow
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
D. Linszen
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
P. Dingemans
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, United Kingdom
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, United Kingdom

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background and Aims

The main aim of the European Prediction of Psychosis Study (EPOS) is to study a large sample of young patients who are at risk of psychosis and to estimate their conversion rate to psychosis during 18 months follow-up. The present presentation aims to describe premorbid adjustment in the patients at risk of psychosis.

Methods

In six European centres (Cologne, Berlin, Turku, Amsterdam, Birmingham, Manchester), 246 psychiatric patients at risk of psychosis were examined. Risk of psychosis was defined by occurrence of basic symptoms, attenuated psychotic symptoms, brief, limited or intermittent psychotic symptoms or familial risk plus reduced functioning during the past three months. Premorbid adjustment was measures by the Premorbid Adjustment Scale (PAS) and correlated with patient's baseline and outcome measures. Psychiatric patients without prodromal symptoms (not at risk) and healthy subjects, studied in one centre, acted as comparison groups.

Results

PAS scores were poorer in the patients at risk of psychosis than in patients without prodromal symptoms or in healthy controls. In adolescence, differences in PAS scores were greater than in childhood or in adulthood. Within patients at risk of psychosis, men had poorer PAS scores than women. Childhood, adolescent and adulthood PAS scores associated extensively with patient's clinical and functional state at baseline examination. Adolescent and adulthood PAS scores correlated also with conversion to psychosis.

Conclusions

Disturbed premorbid psychosocial development, especially from adolescence on, may indicate vulnerability to and onset of psychosis.

Type
S42. Symposium: EPOS-First Results of the Completed Study
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S64
Copyright
Copyright © European Psychiatric Association 2007
Submit a response

Comments

No Comments have been published for this article.