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Predictors of short – and long-term clinical outcome in schizophrenic psychosis – the Northern Finland 1966 Birth Cohort study

Published online by Cambridge University Press:  15 April 2020

P. Juola ,
J. Miettunen ,
J. Veijola ,
M. Isohanni  and
E. Jääskeläinen
P. Juola*
Affiliation:
Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014Oulu, Finland
J. Miettunen
Affiliation:
Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014Oulu, Finland University of Oulu, Institute of Health Sciences, University of Oulu, P.O. Box 5000, 90014Oulu, Finland
J. Veijola
Affiliation:
Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014Oulu, Finland University of Oulu, Institute of Health Sciences, University of Oulu, P.O. Box 5000, 90014Oulu, Finland Oulu University Hospital, Department of Psychiatry, P.O. Box 26, 90029 OYS, Oulu, Finland
M. Isohanni
Affiliation:
Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014Oulu, Finland Oulu University Hospital, Department of Psychiatry, P.O. Box 26, 90029 OYS, Oulu, Finland
E. Jääskeläinen
Affiliation:
Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014Oulu, Finland Oulu University Hospital, Department of Psychiatry, P.O. Box 26, 90029 OYS, Oulu, Finland
*
*Corresponding author. Tel.: +358 08 315 6910; fax: +358 8 336169. E-mail address:[email protected] (P. Juola).
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Abstract

Objective:

Since the outcome in schizophrenia is heterogeneous and often poor, identification of specific predictors of outcome would be useful in clinical practice.

Methods:

Subjects with schizophrenic psychoses (n = 103) included in the Northern Finland 1966 Birth Cohort (n = 12,058), representing the general population, were followed-up for an average of 16.4 years. Predictor and outcome data were collected from the nationwide Finnish Hospital Discharge Register, hospital records and interviews.

Results:

Insidious onset of illness predicted a rehospitalization due to psychosis in the 2 years after the initial discharge. Being single, having an early onset, insidious onset, suicidal ideations upon the first admission, a rehospitalization and a high number of treatment days due to psychosis in the early stages of the illness all predicted a poorer clinical outcome in the longer term, after a minimum follow-up of 10 years.

Conclusions:

This population-based study indicates that clinical and sociodemographic factors around the onset of illness have significance for the long-term outcome in schizophrenia. These prognostic factors should be taken into account in clinical practice.

Keywords

Follow-upLongitudinalPopulation-basedPrognosisRemissionSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 5 , June 2013 , pp. 263 - 268
Copyright
Copyright © European Psychiatric Association

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