Polymorphism neuropeptide receptor gene S (NPSR1) and sleep disturbances

Abstract

Objective

To study the association gene of candidate NPSR1 rs324981 with sleep disorders in the open population of men 45–64 years of Novosibirsk.

Materials and methods

The study of the association candidate gene polymorphisms with sleep disorders was carried out during the examination of a random representative sample of men 45–69 years (n = 1770). The response rate was 61%. The median age is 56.5 year. Every 12 a man was selected for genotyping (n = 147). To assess the level of sleep was used a questionnaire which was filled with self-test. Statistical analysis was performed using SPSS-11.5.

Results

The level of sleep disorders in the male population of 45–64 years was 79.9%. The frequency of homozygous C/C genotype of neuropeptide S (gene NPSR1 rs324981) was 19.4%, T/T genotype occurs in 27.8%, C/T genotype −52.8%. Men dominated the T allele of −54.2%, and the C allele −45.8% growth trend Fnd dissatisfaction with the quality of their sleep among men. Men T-allele carriers, most evaluated their sleep as “satisfactory” in 69% of cases, (χ² = 15,713 df = 8, P < 0.05).

Conclusion

Association found men carrier T-allele of neuropeptide S (gene NPSR1 rs324981), a sleep disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.