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Platelet 3H-imipramine binding in major depressive episodes

Published online by Cambridge University Press:  16 April 2020

G Faludi  and
K Tekes
G Faludi
Affiliation:
Department of Psychiatry, Semmelweis Medical School, Balassa u 6, 1083, Budapest
K Tekes
Affiliation:
Department of Pharmacodynamics, Semmelweis Medical School, Budapest, Hungary
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Summary

Density (Bmax) and affinity constant (Kd) values of tritiated imipramine binding sites were determined on platelets from patients suffering from major depression and from healthy, age-and sex-matched controls. Significantly lower Bmax values were found in the depressed patients, while the Kd values did not differ from those of controls. The results suggest that, in accordance with data from the literature, decrease in 3H-imipramine binding sites may be used as a state-dependent biological marker of depression in clinical practice.

Keywords

3H-imipraminebinding sitesbiological markerdepression
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 2 , 1991 , pp. 73 - 78
Copyright
Copyright © Elsevier, Paris 1991

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