Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2025-01-03T22:14:24.423Z Has data issue: false hasContentIssue false
  • English
  • Français

Platelet 3H-imipramine binding in major depressive episodes

Published online by Cambridge University Press:  16 April 2020

G Faludi  and
K Tekes
G Faludi
Affiliation:
Department of Psychiatry, Semmelweis Medical School, Balassa u 6, 1083, Budapest
K Tekes
Affiliation:
Department of Pharmacodynamics, Semmelweis Medical School, Budapest, Hungary
Get access

Summary

Density (Bmax) and affinity constant (Kd) values of tritiated imipramine binding sites were determined on platelets from patients suffering from major depression and from healthy, age-and sex-matched controls. Significantly lower Bmax values were found in the depressed patients, while the Kd values did not differ from those of controls. The results suggest that, in accordance with data from the literature, decrease in 3H-imipramine binding sites may be used as a state-dependent biological marker of depression in clinical practice.

Keywords

3H-imipraminebinding sitesbiological markerdepression
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 2 , 1991 , pp. 73 - 78
Copyright
Copyright © Elsevier, Paris 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

AΡA Committees on Nomenclature and Statistics (1980) Diagnostic and Statistical Manual of Mental Disorders (DSM III). AΡA, Washington, DCGoogle Scholar
Arora, RMeltzer, H (1986) Effet of adrenalectomy and corticosterone on 3H-imipramine binding in rat blood platelets and brain. Eur J Pharmacol 123, 415–419CrossRefGoogle Scholar
Axelrod, JReisine, Τ (1984) Stress hormones: their interaction and regulation. Science 224, 452–459CrossRefGoogle ScholarPubMed
Berrettini, WHNurnberger, JIPost, RMGershon, ES (1982) Platelet 3H-imipramine binding in euthymic bipolar patients. Psychiatry Res 9, 215–219CrossRefGoogle Scholar
Briley, MSRaisman, RLanger, SZ (1979) Human platelets possess high-affinity binding sites for 3H-imipramine. Eur J Pharmacol 58, 347–348CrossRefGoogle ScholarPubMed
Briley, MSLanger, SZRaisman, RSechter, DZarifian, E (1980) Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209, 303–305CrossRefGoogle ScholarPubMed
Carroll, BJFeinberg, MGreden, JFTarika, JAlbala, AHaskette, RT (1981) A specific laboratory test for the diagnosis of melancholia : standardization, validation and clinical utility. Arch Gen Psychiatry 38, 15–22CrossRefGoogle Scholar
Egrise, DDesmedt, DSchoutens, AMendlewicz, J (1983) Circannual variations in the density of tritiated imipramine binding sites on blood platelets in man. Neuropsychobiology 10, 101–102CrossRefGoogle ScholarPubMed
Egrise, DRubinstein, MSchoutens, AMendlewicz, J (1986) Seasonal variation of platelet serotonin uptake and 3H-imipramine binding in normal and depressed subjects. Biol Psychiatry 21, 283–292CrossRefGoogle ScholarPubMed
Faludi, GMagyar, ITekes, KTóthfalusi, LMagyar, K (1988) Measurement of 3H-serotonin uptake in blood platelets in major depressive episodes. Biol Psychiatry 23, 829–833CrossRefGoogle ScholarPubMed
Friedl, WPropping, Ρ (1984) 3H-imipramine binding in human platelets: a study in normal twins. Psychiatry Res 11, 279–285CrossRefGoogle ScholarPubMed
Galzin, AMLoo, HSechter, DLanger, SZ (1986) Lack of seasonal variation in platelet 3H-imipramine binding in humans. Biol Psychiatry 21, 876–882CrossRefGoogle ScholarPubMed
Hamilton, M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56–62CrossRefGoogle Scholar
Kamal, LARaisman, RMeyer, PLanger, SZ (1984) Reduced V max of 3H-serotonin uptake but unchanged 3H-imipramine binding in the platelets of untreated hypertensive subjects. Life Sci 34, 2083–2088CrossRefGoogle ScholarPubMed
Kanof, PDCoccaro, EFJohns, CASiever, LJDavis, KL (1987) Platelet 3H-imipramine binding in psychiatry disorders. Biol Psychiatry 22, 278–286CrossRefGoogle Scholar
Langer, SZRaisman, R (1983) Binding of 3H-imipramine and 3H-desipramine as biochemical tools for studies in depression. Neuropharmacology 22, 407–413CrossRefGoogle ScholarPubMed
Langer, SZMoret, CRaisman, RDubocovich, MLBriley, MS (1980) High affinity 3H-imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine. Science 210, 1133–1135CrossRefGoogle Scholar
Langer, SZRaisman, RTTahraoui, LScatton, BNiddam, RLee, CRClaustre, Υ (1984a) Substituted tetraphydro-beta-carbolines are possible candidates as endogenous ligands of the 3H-imipramine recognition site. Eur J Pharmacol 98, 153–154CrossRefGoogle Scholar
Langer, SZLee, CRSegonzac, ATateishi, TSchoemaker, HWinblad, B (1984b) Possible endocrine role of the pineal gland for 6-metnoxy-tetrahydro-beta-carboline, a putative endogenous neuromodulator of the 3H-imipramine recognition site. Eur J Pharmacol 102, 379–380CrossRefGoogle Scholar
Langer, SZSechter, DLoo, HRaisman, RZarifian, E (1986) Electroconvulsive shock therapy and maximum binding of platelet tritiated imipramine binding in depression. Arch Gen Psychiatry 43, 949–952CrossRefGoogle ScholarPubMed
Mellerup, ETPlenge, PRosenburg, R (1982) 3H-imipramine binding sites in platelets from psychiatric patients. Psychiatric Res 7, 221–227CrossRefGoogle ScholarPubMed
Munson, PJRodbard, D (1980) LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107, 220–239CrossRefGoogle ScholarPubMed
Nemeroff, CWiderlov, EBissette, GWalleus, HKarlsson, IEklund, KKitts, CLoosen, PVale, W (1984) Elevated concentrations of corticotropin releasing factor-like immunureactivity in depressed patients. Science 226, 1342–1343CrossRefGoogle Scholar
Paul, SMRehavi, MSkolnick, PGoodwin, FK (1980) Demonstration of specific high affinity binding sites for 3H-imipramine on human platelets. Life Sci 26, 953–959CrossRefGoogle ScholarPubMed
Paul, SMRehavi, MSkolnick, PGoodwin, FK (1982) 3H-imipramine binding to the serotonin “transporter” in human brain and platelet : a possible biological marker in depression.In: Biological Markers in Psychiatry and Neurology (Usdin, EHanin, I eds) Pergamon Press, 193–204CrossRefGoogle Scholar
Perry, EKMarshall, EFBlessed, GTomlinson, BEPerry, RH (1983) Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 142, 188–192CrossRefGoogle ScholarPubMed
Peterson, GL (1977) A simplification of the protein assay method of Lowry et al which is more generally applicable. Anal Biochem 83, 346–356CrossRefGoogle Scholar
Pletscher, A (1978) Platelets as models for monoaminergic neurons.In: Assays in Neurochemistry and Neuropharmacology (Youdim, MBHLowenberg, WSharmas, DFLagnado, JR eds) Wiley and Sons, Chichester, vol 3, 50–101Google Scholar
Poirier, MFGalzin, AMLoo, HPimoule, CSegonzac, ABenkelfat, CSechter, DZarifian, ESchoemaker, HLanger, SZ (1987) Changes in [3H]-5-HΤ and 3H-imipramine binding in platelets after chlomipramine in healthy volunteers. Biol Psychiatry 22, 287–302CrossRefGoogle ScholarPubMed
Raismasn, RSechter, DBriley, MSZarifian, ELanger, SZ (1981) High affinity 3H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers. Psychopharmacology 75, 368–371CrossRefGoogle Scholar
Raisman, RBriley, MSBouchami, FSechter, DZarifian, ELanger, SZ (1982) 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers. Psychopharmacology 77, 332–335CrossRefGoogle ScholarPubMed
Rehavi, MSkolnick, PPaul, SM (1985) Characterization of high affinity antidepressant binding to rat and human brain.In: Proc 3rd Int Meet Clinical Pharmacology in Psychiatry (Gram, LUsdin, E eds) Macmillan,London, 846–853Google Scholar
Roy, APickar, DPaul, S (1984) Biological tests for depression. Psychosomatics 25, 343–351CrossRefGoogle Scholar
Suranyi-Cadotte, BEWood, PLNair, NPVSchwartz, G (1982) Normalization of platelet 3H-imipramine binding in depressed patients during remission. Eur J Pharmacol 85, 357–358CrossRefGoogle ScholarPubMed
Suranyi-Cadotte, BE (1984) 3H-imipramine binding in human platelets. Prog Neuropsychopharmacol & Biol Psychiatry 8: 737–741CrossRefGoogle Scholar
Tang, SWMorris, JM (1985) Variation in human platelet 3H-imipramine binding. Psychiatry Res 16, 141–146CrossRefGoogle ScholarPubMed
Tuomisto, JTukiainen, E (1976) Decreased uptake of 5-hydroxy-tryptamine in blood platelets from depressed patients. Nature (Lond) 262, 596–598CrossRefGoogle ScholarPubMed
Wagner, AAberg-Wistedt, Asberg, ABertilsson, LMartensson, BMontero, D (1987) Effect on platelet tritiated imipramine binding in major depressive disorder. Arch Gen Psychiatry 44, 870–877CrossRefGoogle Scholar
Whitaker, PMWarsh, JJStancer, HCPersad, EVint, CK (1984) Seasonal variation in platelet 3H-imipramine binding, comparable values in control and depressed populations. Psychiatry Res 11, 127–131CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.