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Physiological strength of lipoic acid in copper intoxication

Published online by Cambridge University Press:  01 September 2022

J. Jovanovic Mirkovic ,
G. Kocic ,
C. Alexopoulos  and
Z. Jurinjak
J. Jovanovic Mirkovic*
Affiliation:
The Academy of Applied Preschool Teaching and Health Studies, Biochemistry, Cuprija, Serbia
G. Kocic
Affiliation:
Faculty of Medicine, Biochemistry, Nis, Serbia
C. Alexopoulos
Affiliation:
The Academy of Applied Preschool Teaching and Health Studies, Cuprija, Serbia, Medicine, Cuprija, Serbia
Z. Jurinjak
Affiliation:
The Academy of Applied Preschool Teaching and Health Studies, Cuprija, Serbia, Medicine, Cuprija, Serbia
*
*Corresponding author.

Abstract

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Introduction

The average concentration of copper in the air, e.g. in the USA it ranges from 5–20 ng/m3, in soil from 5–70 mg/kg, and the intake of copper from food is 1.0–1.3 mg/days for adults (0.014–0.019 mg/kg/day) (Barceloux, 1999). The effect of lipoic acid is reflected in the intensification of ATP synthesis, participates in the assimilation of lactic acid, activates the enzyme cycle of tricarboxylic acid, stimulates the growth of lactic acid bacteria by replacing acetate (acetate transfer factor), stimulates CoA synthesis (fatty acid utilization), prevents liver damage by various toxins, normalizes aldolase and transferase levels.

Objectives

The aim of this study is to show the useful role of a supplement, lipoic acid, as an antioxidant in the prevention of oxidative stress.

Methods

All procedures were performed after anesthesia of albino rats with ketal in accordance with the principles of sacrifice in laboratories. After medial laparotomy albino rates Wistar soy, a 10% homogenate of brain tissue was made in an appropriate medium and an analysis of acid and alkaline DNase activity was performed (Kocić i sar., 2004).

Results

DNases are thought to be the main executors of apoptosis, responsible for internucleosomal DNA fragmentation, which is the breakdown of chromosomal DNA into oligonucleosome-sized fragments. Administration of lipoic acid has been shown to protect against oxidative stress caused by copper.

Conclusions

Based on the results of this research, it can be concluded that lipoic acid is a powerful and powerful antioxidant.

Disclosure

No significant relationships.

Keywords

Lipoic acidcopperintoxication
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S222
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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