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Peripersonal space plasticity in Schizophrenia: a motor training

Published online by Cambridge University Press:  01 September 2022

F. Magnani ,
F. Ferroni ,
F. Ferri ,
M. Ardizzi ,
N. Langiulli ,
F. Giustozzi ,
F. Rasmi ,
R. Volpe ,
V. Lucarini  and
C. Marchesi
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F. Magnani*
Affiliation:
University of Parma, Department Of Neuroscience, Psychiatric Unit, Parma, Italy
F. Ferroni
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Parma, Italy
F. Ferri
Affiliation:
University G. D’Annunzio, Chieti, Department Of Neuroscience, Imaging And Clinical Science, chieti, Italy
M. Ardizzi
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Parma, Italy
N. Langiulli
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Parma, Italy
F. Giustozzi
Affiliation:
University of Parma, Department Of Neuroscience, Psychiatric Unit, Parma, Italy
F. Rasmi
Affiliation:
University of Parma, Department Of Neuroscience, Psychiatric Unit, Parma, Italy
R. Volpe
Affiliation:
University of Parma, Department Of Neuroscience, Psychiatric Unit, Parma, Italy
V. Lucarini
Affiliation:
Université de Paris, Équipe Physiopathologie Des Maladies Psychiatriques, Umr 1266 Ipnp Inserm, Paris, France
C. Marchesi
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Psychiatric Unit, Parma, Italy
V. Gallese
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Parma, Italy Humboldt-Universit¨at zu Berlin, Berlin School Of Mind And Brain, Berlin, Germany
M. Tonna
Affiliation:
University of Parma, Department Of Medicine & Surgery, Unit Of Neuroscience, Psychiatric Unit, Parma, Italy
*
*Corresponding author.

Abstract

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Introduction

A primary disruption of the bodily self is considered a core feature of schizophrenia patients (SCZ). The “disembodied” self would be underpinned by an inefficient body-related multisensory integration mechanism occurring in the Peripersonal Space (PPS). PPS is a plastic sector of space surrounding our body, whose extent is altered in SCZ. Although PPS represents a malleable interface marking the perceptual border between self and others, no study has investigated the potential alteration of its plasticity in SCZ.

Objectives

We investigated the PPS extension and its plasticity in SCZ and their potential correlations with the clinical scales.

Methods

Thirty SCZ and thirty healthy controls (HC) underwent a multisensory task to estimate PPS boundary before and after a motor training. Patients were also administered the Positive And Negative Syndrome Scale (PANSS) and the Examination of Anomalous Self-Experience (EASE).

Results

Data confirm a narrower PPS extent in SCZ than in HC, whereas no differences in PPS expansion was found in the two groups after the motor training (Figure 1). Positive symptoms were associated directly with PPS extent and inversely with PPS plasticity. No associations were found between PPS and EASE domains. Figure1: Graphical representation of PPS expansion in SCZ and HC. Both panels show individual normalized sigmoid fits

Conclusions

The present study suggests a narrower PPS extent and a preserved PPS plasticity in SCZ with respect to HC. Both PPS extent and plasticity are related to the severity of positive symptoms. These results highlight the potential role of rehabilitation interventions in order to improve patients’ weakened body boundary.

Disclosure

No significant relationships.

Keywords

schizophréniamotor trainingPsychosisperipersonal space
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S312
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Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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