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Patient outcomes in schizophrenia II: the impact of cognition

Published online by Cambridge University Press:  16 April 2020

Alex Hofer ,
Susanne Baumgartner ,
Thomas Bodner ,
Monika Edlinger ,
Martina Hummer ,
Georg Kemmler ,
Maria A. Rettenbacher  and
W. Wolfgang Fleischhacker
Alex Hofer*
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Susanne Baumgartner
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Thomas Bodner
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Monika Edlinger
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Martina Hummer
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Georg Kemmler
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
Maria A. Rettenbacher
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
W. Wolfgang Fleischhacker
Affiliation:
Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020Innsbruck, Austria
*
*Corresponding author. Tel.: +43 512 504 23669; fax: +43 512 50425267. E-mail address:[email protected] (A. Hofer).
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Abstract

Background

Cognitive dysfunction is increasingly considered to be the strongest clinical predictor of poor long-term outcome in schizophrenia. Associations have been found between the severity of cognitive deficits and social dysfunction, impairments in independent living, occupational limitations, and disturbances in quality of life (QOL).

Methods

In this cross-sectional study, the relationships of cognitive deficits and treatment outcomes in terms of QOL, needs, and psychosocial functioning were examined in 60 outpatients with schizophrenia who had a duration of illness over 2 years and had been treated with either clozapine or olanzapine for at least 6 months.

Results

The present study suggests that cognitive functioning might be a predictor of work functioning/independent living outcome in stabilized patients with schizophrenia: deficits of visual memory and working memory were negatively associated with occupational functioning, and older patients lived independently and/or in a stable partnership more often. The patients' assessments of QOL and needs for care did not show any significant associations with cognitive functioning.

Discussion

These findings suggest that cognitive functioning is a key determinant of work functioning/independent living for stable outpatients with schizophrenia.

Keywords

SchizophreniaCognitionOutcomeNeedsQuality of lifeEmployment
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 5-6 , August 2005 , pp. 395 - 402
Copyright
Copyright ©Elsevier SAS 2005

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