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P-53 - the Effect of Administration of a Single Methadone Dose on Psychomotor Performance in Patients Addicted to Opioids During Substitution Therapy

Published online by Cambridge University Press:  15 April 2020

E. Gorzelańczyk ,
W. Lasoń ,
I. Raniszewska ,
M. Ziółkowski ,
J. Feit ,
P. Walecki  and
S. Biedrzycki
E. Gorzelańczyk
Affiliation:
Institute of Psychology, Polish Academy of Sciences, Warszawa, Swiecie, Poland
W. Lasoń
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Krakow, Swiecie, Poland
I. Raniszewska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Swiecie, Poland
M. Ziółkowski
Affiliation:
Department of Psychiatry Nursing, Collegium Medicum of Nicolaus Copernicus University in Torun, Swiecie, Poland
J. Feit
Affiliation:
Non-Public Health Care Center Sue Ryder Home, Collegium Medicum of Nicolaus Copernicus University in Torun, Bydgoszcz, Swiecie, Poland
P. Walecki
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Krakow, Swiecie, Poland
S. Biedrzycki
Affiliation:
Provincial Hospital for Neurotic and Mentally III, Swiecie, Poland

Abstract

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Objective

The aim of the study is to assess graphomotor and psychomotor skills of people treated with substitution therapy in opiate addiction.

Methods

36 patients were examined twice, immediately before and about 1.5h after oral administration of therapeutic dose of methadone. The original test implemented on a tablet was used. A task in the first part was to map, as accurately as possible, geometric shapes printed on the sheet of paper by drawing on contour, and in the second part to sign up on the sheet. The patients used dominant hand. The software used allows to make analysis of the motion's parameters: time, force levels, speed and acceleration of the plot, amplitude and frequency of hand tremors.

Results

The amplitude of tremors in the spectrum of variations in 13 of the 16 components analyzed in the drawing task and all the components in the spectrum of the instantaneous velocity tremors were reduced. In the signature task a significant reduction in the average amplitude of tremors for medium and higher spectral components (from the 4th up) and a reduction in the amplitude of tremors in the spectrum of instantaneous velocity for most precisely analyzed components was observed.

Conclusion

A single dose of methadone in opioid-addicted individuals reduces dominant hand tremors, particularly in the 1st spectrum component frequency for the drawing test. This indicates improvement in graphomotor and psychomotor function.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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