P-366 - Significance of Cognitive Neuroscience in Patients With Psychogenic Tremor

Abstract

Background:

Yet, little is known regarding the significance of cognitive neuroscience, especially the using of its indices as biomarkers for Psychogenic tremor (PsTr).

Aims and objective:

To investigate whether the cognitive neuroscience have a significance in patients with PsTr, in particular for the purposes of the screening and monitoring of the disorder.

Methods:

Thirty-five patients with PsTr (mean age 61.29 ± 11.74 years, range 12–90 years) were investigated. As control groups served thirty-four patients with Essential tremor (mean age 59.71 ± 12.60 years, range 11–86 years), thirty-one patients with Parkinson's disease (mean age 61.24 ± 12.74 years, range 12–89 years), and thirty-two clinically healthy individuals (mean age 27.14 ± 9.17 years, range 17–37 years). Both simple and complex cognitive neuroscience's indices were examined. We applied ANOVA-test, correlation and simple as well multiple regression analyses.

Results:

The performed differential comparative analysis of the investigated parameters of the cognitive neuroscience's indices revealed that the most informative (p < 0.05) factors (in descending series of the informative-ness) were as follows: 1. complex cognitive neuroscience's index with differential informativeness 0.96; 2. simple cognitive neuroscience's index with differential informativeness 0.93. Similar (p < 0.05) groups in conformity with the investigated nosological groups were obtained.

Conclusion:

The results we obtained showed that the cognitive neuroscience may have an implication (p < 0.05) for screening and monitoring of Psychogenic tremor.