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P300 Correlates of Cognitive Dysfunctions in Schizophrenia

Published online by Cambridge University Press:  15 April 2020

G. Di Lorenzo ,
A. Mucci ,
A. Daverio ,
F. Ferrentino ,
A. Vignapiano ,
P. Romano ,
M. Ribolsi ,
C. Niolu ,
V. Montefusco  and
G. Plescia
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G. Di Lorenzo
Affiliation:
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
A. Mucci
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
A. Daverio
Affiliation:
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
F. Ferrentino
Affiliation:
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
A. Vignapiano
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
P. Romano
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
M. Ribolsi
Affiliation:
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
C. Niolu
Affiliation:
Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
V. Montefusco
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
G. Plescia
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
O. Gallo
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy
S. Galderisi
Affiliation:
Department of Psychiatry, University of Naples SUN, Naples, Italy

Abstract

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Introduction

P300 is an event-related potential (ERP) thought to reflect attention, working memory and context integration and has been shown to be consistently reduced in patients with Schizophrenia. Despite a possible relation between P300 components and cognitive deficits in Schizophrenia has been hypothesized, few studies addressed this hypothesis.

Objectives

In the context of a multicenter study of the Italian Network for Research on Psychoses, our study focused on the investigation of auditory P300 component in relation to clinical and cognitive domains in patients with Schizophrenia.

Methods

ERPs were recorded in 64 chronic, stabilized patients with Schizophrenia during a standard oddball task. N1 and P3b latency and amplitude were assessed at Fz and Pz, respectively. State of art instruments was used for clinical assessment. Cognitive indices (from the seven cognitive domains of the Measurement and Treatment of Cognition in Schizophrenia, MATRICS) were expressed as Z-scores from an Italian normative sample.

Results

Correlation analysis revealed associations of P3b latency with age, education, PANSS-DIS, processing speed, working memory, St. Hans parkinsonism subscale. In a multiple linear regression model, processing speed was an independent significant predictor of P3b latency.

Conclusion

For the first time, a strong relation between P3b latency and processing speed impairment was shown in Schizophrenia. Processing speed is considered a central factor in the relation between cognitive deficits and functional outcome in chronic schizophrenia. The association with P3b latency might shed lights in the neural basis of this complex construct.

Type
Article: 0248
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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