P-1302 - Relationship Between Metabolic Syndrome and Clinical Features of Schizophrenia

Abstract

Objective

The aim of this study was to evaluate the prevalence of metabolic syndrome and metabolic syndrome criteria in patients with schizophrenia and also to investigate the effects of metabolic syndrome on medical treatment, clinical course.

Method

One hundred-sixteen patients with schizophrenia were consecutively admitted. Waist circumference, blood pressure, body weight and height were measured, and body mass index was calculated. Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Calgary Depression Scale for Schizophrenia were applied to the patients.

Results

The frequency of metabolic syndrome according to IDF criteria was 42.2% among the patients (46.9% for female and 38.8% for male patients). There was no significant difference between patients with and without metabolic syndrome in terms of age. The frequencies of metabolic syndrome were 62.5% for together taken typical and atypical antipsychotics and 35.7% for taken two or more atypical antipsychotics, whereas the rates of metabolic syndrome of taken only one atypical and only one typical antipsychotics were 45.1% and 13.3%, respectively. The duration of disease in patients with metabolic syndrome was higher than those without.

Conclusion

In this study, the frequency of metabolic syndrome in patients with schizophrenia was consistent with the results of previous studies in our country. Our findings showed that the duration of illness, high scores of BMI, use of clozapine or concurrent use of typical and atypical antipsychotics, depressive and negative symptoms of schizophrenia were significant risk factors.