P-1276 - the Functional Brain's Asymmetry According to the Dimensional Model of Schizophrenia

Abstract

Introduction

Three clinical “dimensions” are identified for schizophrenia: positive (delusions, hallucinations, thought automatism), disorganization (inappropriate affect, bizarre behavior, formal-thought disorders), negative (affective flattening, alogia, abulia-apathy, anhedonia-asociality).

Objectives

To evaluate Individual Profile of Functional Asymmetry (IPFA) influence on schizophrenia's clinical polymorphism.

Aims

To compare IPFA in 90 healthy subjects and 90 schizophrenic patients in three clinical groups, depending on prevalence of positive, negative symptoms or disorganization.

Methods

SAPS/SANS; dichotic listening; test “card with the hole”, “viewing through a telescope”; accuracy of tracking and key press speed tests; SPSS’10.0. The coefficient of right ear (CRE), the coefficient of right hand (CRH) were calculated; seven IPFA types determined by CRH/CRE ratio, depending on function's laterality type and degree.

Results

Patients unlike controls revealed: higher frequency of right-sided hearing asymmetry (50% vs. 22%), higher average values of CRE (9,57% vs. 3,1%) and |CRE| (19,98% vs. 10,63%), higher rates of IPFA types with minimal excess |CRH| over |CRE| (less than 5 times) (30% vs.20%) and “inverted” types (|CRE|>|CRH|) (15.5% vs. 5.5%). Controls were more likely to have large predominance of CRH over CRE (more than 5 times) (17.8% vs. 5.6%).Ambidexterity dominated in “negative” dimension group, right hand prevailed in others. Positive symptoms degree directly correlated with CRE. “Negative” type inversely correlated with CRH and |CRH|.

Conclusions

Increased right-sided hearing asymmetry points to verbal agnosia of signals coming from the left-side auditory space, which is more related to positive symptoms; negative symptoms are more related to motor function's symmetry. Protective and promoting IPFA types determined.