P-1272 - Cardiovascular Risk in Patients With First Episode of Schizophrenia

Abstract

Background

Cardiovascular illness may partly explain why patients with schizophrenia die at least 20 years earlier than general population. Monitoring and screening for cardiovascular risk factors was recently recommended in schizophrenia treatment guidelines. High-sensitivity C-reactive protein (hsCRP) is one of the inflammation mediators that has been widely used as a biomarker for predicting the occurrence of future cardiovascular (incl. thromboembolism) events in somatic medicine, but not in psychiatry.

Methods

In the prospective ANTRE (ANtipsychotics ThRombosis Embolism) study we investigated the plasma levels of hsCRP and lipids and measured weight and BMI (Body Mass Index) in a group of thirty patients (seventeen males and thirteen females) with newly diagnosed psychosis (mean age 28.2 ± 8.0, range 18–52 years). Control group consisted of thirty-one healthy volunteers matched for age, gender and body mass index. We evaluated the haemostatic parameters at the time of admission and after three and twelve months during antipsychotic treatment.

Results

Weight (mean 67.6 versus 77.2; P = 0.00002), BMI (median 21.6 versus 26.1; P = 0.001), hsCRP (median 1.0 versus 2.5; P = 0.0009), total cholesterol (4.6 versus 5.3; P = 0.016) and atherogenity index (2.1 versus 3.0; P = 0.016) were significantly increased in the study group compared to controls.

Conclusions

We found increased markers of cardiovascular risk in patients with psychosis during first year of treatment. Particularly increase of hsCRP may be associated with cardiovascular events in schizophrenia patients.