P-1201 - Antipsychotic Therapy and Biochemical Laboratory Profile Characterization of a Sample of Patients Diagnosed With Schizophrenia

Abstract

Introduction

Schizophrenia (SCZ) patients are reported to present significant abnormalities in lipid and glucose metabolism, that increase the risk for cardiovascular disease and diabetes, possibly induced by antipsychotic therapy (APT) and lifestyle.

Objectives/Aims

Characterize a sample of SCZ patients relating APT and biochemical laboratory profile.

Methods

We conducted a retrospective longitudinal study of SCZ patients’ records from Psychiatry Service of Hospital S.João (Porto, Portugal) from 2009 to 2011.

Results

The study included 51 SCZ patients of which 82.4% (n = 42) were male, presenting a mean age of 39.3 ± 9.2 years. The most frequent subtype of SCZ was paranoid (90.0%). The average age of diagnosis was 24.5 ± 8.4 years old. Oral APT was prescribed to 48 patients. Depot APT were prescribed to 40 patients. Haloperidol and risperidona were in both cases the most frequent drugs. 50% of patients presented high total cholesterol values (≥200 mg/dL), 25% high LDL cholesterol (≥160 mg/dL), 81% low HDL cholesterol (≤40/50 mg/dL) and 44% presented high triglycerides results (≥150 mg/dL). 27% of patients presented impaired fasting glucose values (110 to 125 mg/dl) and 27% presented at least one plasma glucose result that meet the criteria for diabetes diagnosis (≥126 mg/dl). There was an overall increase in hepatic enzymes (54% ALT, 36% AST and GGT).

Conclusions

Hepatic metabolism of APT may explain elevated liver enzimes. Lipid and glucose profiles in our sample clearly indicate the need of monitoring SCZ patients, managing APT side effects and lowering risk. We encourage clinicians to record metabolic monitoring and to establish corrective measures (food, lifestyle and medication).