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P-07 - Association of the Drd2 Taqia, 5-ht1b a-161t and Cnr1 1359 g/a Polymorphisms With Alcohol Dependence: a Single Center Experience in Denizli Province of Turkey

Published online by Cambridge University Press:  15 April 2020

C. Balci Sengul ,
M.E. Erdal ,
C. Sengul ,
Ö. İzci Ay ,
M. Efe ,
M.E. Ay  and
H. Herken
C. Balci Sengul
Affiliation:
Psychiatry, Denizli State Hospital, Denizli, Turkey
M.E. Erdal
Affiliation:
Genetics, Mersin University, Mersin, Denizli, Turkey
C. Sengul
Affiliation:
Psychiatry, Denizli, Turkey
Ö. İzci Ay
Affiliation:
Genetics, Mersin University, Mersin, Denizli, Turkey
M. Efe
Affiliation:
Genetics, Pamukkale University, Denizli, Turkey
M.E. Ay
Affiliation:
Genetics, Mersin University, Mersin, Denizli, Turkey
H. Herken
Affiliation:
Psychiatry, Denizli, Turkey

Abstract

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Alcohol dependence is associated with genetic variants of alcohol-metabolizing enzymes and genes related to dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Genetic variations in the endogenous cannabinoid system are also involved in alcohol dependence. The present study aimed to evaluate the association between three polymorphisms, DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A (rs1049353), and alcohol dependence. One hundred twenty three patients who were admitted to the Alcohol and Substance Abuse Center of Denizli State Hospital and diagnosed with alcohol dependence according to the DSM-IV criteria and 125 healthy volunteers were included in the study. Of the three polymorphisms investigated, 5-HT1B A-161T was the only one found to be associated with alcohol dependence. The 5-HT1B receptor A-161T polymorphism might be a promising marker for alcohol dependence; however, future studies are needed to clarify these findings.

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Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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