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P-06 - Mortality Following Treatment for Cannabis use Disorders: Causes, Predictors, and Time of Death

Published online by Cambridge University Press:  15 April 2020

M. Arendt ,
P. Munk-Jørgensen ,
L. Sher  and
S.O.W. Jensen
M. Arendt
Affiliation:
Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University, Columbia University and New York State Psychiatric Institute, New York, NY, USA
P. Munk-Jørgensen
Affiliation:
Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark, Columbia University and New York State Psychiatric Institute, New York, NY, USA
L. Sher
Affiliation:
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA
S.O.W. Jensen
Affiliation:
Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University, Columbia University and New York State Psychiatric Institute, New York, NY, USA

Abstract

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Aims

This study estimated Standardized Mortality Ratios (SMRs) for accidents, suicide, homicide, and natural causes following treatment for cannabis use disorders. Predictors of death within the sample and the time of death in relation to treatment start and ending were determined.

Methods

This was a register-based cohort study of 6445 individuals in treatment for cannabis use disorders in Denmark between 1996 and 2006. The register of individuals in treatment for cannabis use disorders was linked with registers on causes of death and psychiatric treatment. The sample was followed after treatment entry and 142 deaths were recorded during 26584 person-years of follow-up.

Results

The all-cause Standardized Mortality Ratio (SMR) was 4.9. For different causes of death the SMRs were: accidents: 8.2 (95% CI 6.3–10.5), suicide: 5.3 (95% CI 3.3–7.9), homicide: 3.8 (95% CI 1.5–7.9), and natural causes: 2.8 (95% CI 2.0–3.7). Secondary opioid use predicted all-cause mortality as well as death from accidents and homicide, while higher age predicted all-cause mortality and death from natural causes. After exclusion of those with secondary opioid use, excess mortality from homicide was no longer observed, while SMR's associated with other causes of death remained largely unchanged. The SMR was 17 in the first two weeks after treatment start, fell during the following year, and rose again thereafter. No excess mortality was observed following the end of treatment.

Conclusions

Individuals with cannabis use disorders have highly increased mortality from accidents, suicide, homicide, and natural causes.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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