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P0372 - The effect of repetitive transcranial magnetic stimulation add on serotonin reuptake inhibitors in panic disorder

Published online by Cambridge University Press:  16 April 2020

J. Prasko ,
M. Bares ,
J. Horacek ,
M. Kopecek ,
T. Novak ,
B. Paskova ,
J. Vyskocilova  and
R. Zalesky
J. Prasko
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
M. Bares
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
J. Horacek
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
M. Kopecek
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
T. Novak
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
B. Paskova
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
J. Vyskocilova
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic
R. Zalesky
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center of Neuropsychiatric Studies, Prague, Czech Republic

Abstract

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Background:

The Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate the cortical activity. The goal of our study was to assess whether the rTMS would facilitate effect of serotonin reuptake inhibitors in patients suffering from panic disorder.

Method:

Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We used 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study. The psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.

Results:

Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.

Conclusion:

The low frequency Repetitive Transcranial Magnetic Stimulation administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham the Repetitive Transcranial Magnetic Stimulation that was add on serotonin reuptake inhibitors in patients suffering from panic disorder.

Supported by the project n. MŠMT ČR 1M0517

Type
Poster Session I: Brain Imaging
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S190 - S191
Copyright
Copyright © European Psychiatric Association 2008
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