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P0359 - Imaging of the serotin-2A receptor in the canine brain: Before a d after pipamperone administration

Published online by Cambridge University Press:  16 April 2020

K. Audenaert ,
B. De Spiegeleer ,
E. Buntinx ,
V. Vergote ,
E. Vandermeulen ,
S. Vermeire ,
A. Dobbeleir ,
F. De Vos  and
K. Peremans
K. Audenaert
Affiliation:
Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, University Gent, Gent, Belgium
B. De Spiegeleer
Affiliation:
Drug Quality and Registration (DRUQUAR), Faculty of Pharmaceutical Sciences, Univeristy Gent, Gent, Belgium
E. Buntinx
Affiliation:
Drug Quality and Registration (DRUQUAR), Faculty of Pharmaceutical Sciences, Univeristy Gent, Gent, Belgium
V. Vergote
Affiliation:
Drug Quality and Registration (DRUQUAR), Faculty of Pharmaceutical Sciences, Univeristy Gent, Gent, Belgium
E. Vandermeulen
Affiliation:
Department of Medical Imaging, Faculty of Veterinary Sciences, University Gent, Gent, Belgium
S. Vermeire
Affiliation:
Department of Medical Imaging, Faculty of Veterinary Sciences, University Gent, Gent, Belgium
A. Dobbeleir
Affiliation:
Department of Medical Imaging, Faculty of Veterinary Sciences, University Gent, Gent, Belgium
F. De Vos
Affiliation:
Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, University Gent, Gent, Belgium
K. Peremans
Affiliation:
Department of Medical Imaging, Faculty of Veterinary Sciences, University Gent, Gent, Belgium Anima Research Centre, Alken, Belgium

Abstract

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Background and Aims:

Recent publications have drawn attention to the role of serotonin-2A receptors in mood disorders. Low doses of atypical antipsychotics, like the butyrophenone pipamperone, are suggested as an augmentation strategy in the antidepressant treatment of mood disorders, in addition to conventional antidepressant therapies.

Functional imaging studies with highly specific receptor ligands allow quick assessment of drug-receptor occupancy at different doses of drugs - here pipamperone at 5mg and 10mg doses - in a large animal model.

Methods:

Three healthy drug-naïve female Beagle dogs, aged 7 years, were included.

Dogs were scanned before treatment and after administration of one dose of pipamperone of 5mg and 10 mg, 90 minutes prior to injection of the tracer. Acquisition was performed under general anaesthesia 90 minutes after injection of the tracer. The acquisition for both investigations was performed with a triple head gamma camera equipped with LEHR collimators. The images were reconstructed with HOSEM iterative reconstruction and application of a Butterworth-postfilter (cut-off 1,2 cycles/cm, order 8).

Results:

The mean binding serotonin-2A binding index before treatment in the frontal cortex was 1.47. In the 5 mg pre-treatment condition, the binding index was reduced to 1.29 and in the 10 mg pre-treatment condition, it was reduced to 1.04. Non-parametric statistics (Friedman related-samples test) yielded a p-value of 0.05.

Conclusion:

Even in the very low dose range (5mg-10mg) of pipamperone, there was a significant and dose-dependent reduction in serotonin-2A binding index in the three dogs.

Type
Poster Session I: Brain Imaging
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S187
Copyright
Copyright © European Psychiatric Association 2008
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