Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-21T07:49:46.753Z Has data issue: false hasContentIssue false
  • English
  • Français

P0343 - Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders

Published online by Cambridge University Press:  16 April 2020

J.M. Mercader ,
E. Saus ,
Z. Agüera ,
M. Bayés ,
B. Claudette ,
A. Carreras ,
R. de Cid ,
M. Dierssen ,
F. Fernández-Aranda  and
L. Forcano
...Show all authors
J.M. Mercader
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain
E. Saus
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain
Z. Agüera
Affiliation:
CIBER Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Barcelona, Spain
M. Bayés
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain
B. Claudette
Affiliation:
Hospital Louis Mourier, Pr Ades Department, Paris, France
A. Carreras
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain
R. de Cid
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain
M. Dierssen
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER Enfermedades Raras (CIBERER), Barcelona, Spain
F. Fernández-Aranda
Affiliation:
CIBER Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Barcelona, Spain Department of Psychiatry, University Hospital of Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain
L. Forcano
Affiliation:
CIBER Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Barcelona, Spain
P. Gorwood
Affiliation:
Hospital Louis Mourier, Pr Ades Department, Paris, France
J. Hebebrand
Affiliation:
Rheinische Kliniken Essen, Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
A. Hinney
Affiliation:
Rheinische Kliniken Essen, Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
A. Puig
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain
M. Ribases
Affiliation:
Department of Psychiatry, Hospital Universitari Vall D'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
M. Gratacòs
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain
X. Estivill
Affiliation:
Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona, Spain CIBER En Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain National Center of Genotyping (CEGEN), Barcelona Node, Barcelona, Spain Experimental and Health Sciences Department, Pompeu Fabra University, Barcelona, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Eating disorders (ED) are complex psychiatric diseases that include anorexia nervosa and bulimia nervosa, and have higher than 50% heritability. Previous studies have found association of BDNF and NTRK2 to ED, while animal models suggest that other neurotrophin genes might also be involved in eating behavior. We have performed a family based association study with 151 TagSNPs covering ten neurotrophin signaling genes: NGFB, BDNF, NTRK1, NGFR/p75, NTF4/5, NTRK2, NTF3, NTRK3, CNTF and CNTFR in 371 ED trios of Spanish, French and German origin. Besides several nominal associations, we found a strong significant association after correcting for multiple testing (p = 1.04 x 10-4) between ED and rs7180942, located in the NTRK3 gene, which followed an overdominant model of inheritance. Interestingly, HapMap unrelated individuals carrying the rs7180942 risk genotypes for ED showed higher levels of expression of NTRK3 in lymphoblastoid cell lines. Furthermore, higher expression of the orthologous murine Ntrk3 gene was also detected in the hypothalamus of the anx/anx mouse model of anorexia. Finally, variants in NGFB gene appear to modify the risk conferred by the NTRK3 rs7180942 risk genotypes (p = 4.0 x 10-5) showing a synergistic epistatic interaction. The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for eating disorders.

Type
Poster Session I: Eating Disorders
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S182
Copyright
Copyright © European Psychiatric Association 2008
Submit a response

Comments

No Comments have been published for this article.