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P0339 - Suicide attempts in bulimia nervosa: Personality, Psychopathological and Genetic correlates

Published online by Cambridge University Press:  16 April 2020

L. Forcano ,
F. Fernandez-Aranda ,
E.M. Alvarez-Moya ,
C.M. Bulik ,
A. Carracedo ,
R. Granero ,
M. Gratacos ,
S. Jimenez-Murcia ,
I. Krug  and
J.M. Mercader
...Show all authors
L. Forcano
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain Ciber Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Instituto Salud Carlos III, Madrid, Spain
F. Fernandez-Aranda
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain Ciber Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Instituto Salud Carlos III, Madrid, Spain
E.M. Alvarez-Moya
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain Ciber Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Instituto Salud Carlos III, Madrid, Spain
C.M. Bulik
Affiliation:
Departments of Psychiatry and Nutrition, University of North Carolina, Chapel Hill, NC, USA
A. Carracedo
Affiliation:
Fundacion Publica Galega de Medicina Xenomica, SERGAS / Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain Centro Nacional de Genotipado and Grupo de Medicina Xenomica, Santiago de Compostela University, Santiago de Compostela, Spain
R. Granero
Affiliation:
Autonoma University of Barcelona, Barcelona, Spain
M. Gratacos
Affiliation:
Genetic Causes of Disease Group, Genes and Disease Program Center for Genomic Regulation (CRG-UPF), Barcelona, Spain CIBER En Epidemiologia Y Salud Publica (CIBERESP), Madrid, Spain
S. Jimenez-Murcia
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain Ciber Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Instituto Salud Carlos III, Madrid, Spain
I. Krug
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain Ciber Fisiopatologia Obesidad Y Nutricion (CIBEROBN), Instituto Salud Carlos III, Madrid, Spain
J.M. Mercader
Affiliation:
Genetic Causes of Disease Group, Genes and Disease Program Center for Genomic Regulation (CRG-UPF), Barcelona, Spain CIBER En Epidemiologia Y Salud Publica (CIBERESP), Madrid, Spain
E. Saus
Affiliation:
Genetic Causes of Disease Group, Genes and Disease Program Center for Genomic Regulation (CRG-UPF), Barcelona, Spain CIBER En Epidemiologia Y Salud Publica (CIBERESP), Madrid, Spain
J. Santamaria
Affiliation:
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain
X. Estivill
Affiliation:
Genetic Causes of Disease Group, Genes and Disease Program Center for Genomic Regulation (CRG-UPF), Barcelona, Spain CIBER En Epidemiologia Y Salud Publica (CIBERESP), Madrid, Spain Department of Health and Experimental Life Sciences / Pompeu Fabra University (UPF), Barcelona, Spain

Abstract

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Objectives:

Explore the prevalence of lifetime suicide attempts in women with bulimia nervosa (BN), and compare eating disorder symptoms, general psychopathology, impulsivity, personality, and genetic variants in four candidate genes of the serotonin pathway: the serotonin transporter (SLC6A4), serotonin receptors 1A (HTR1A) and 2A (HTR2A) and tryptophan hydroxylase 1 (TPH1) between individuals who had and had not attempted suicide. Determine the best predictors of suicide attempts.

Method:

566 consecutively admitted BN outpatients (417 BN purging, 47 BN non-purging and 102 subthreshold BN). Patients completed a comprehensive assessment battery.

Results:

Lifetime prevalence of suicide attempts was 26.9% CI 95%: 23.2 to 30.5). BN subtype was not associated with lifetime suicide attempts (p=0.36). Compared to non-attempters, attempters exhibited higher unemployment, eating disorder symptomatology, general psychopathology, previous eating disorder treatment, impulsive behaviors, and lower educational level (p<0.004). In relation to personality traits, suicide attempters exhibited significantly (p<0.002) higher Harm Avoidance and lower Self-directedness, Reward Dependence and Cooperativeness. No significant differences in any of the genetic variants between attempters and non-attempters. The best predictors of suicide attempts were (p<0.006): lower education, minimum BMI, previous eating disorder treatment, family history of alcoholism and self-directedness.

Conclusion:

Suicidality in BN patients appears to be within the range previously found. Our results support that internalizing personality traits combined with impulsivity may increase the probability of engaging in suicidal behaviors in these patients. Our data do not support the hypothesis that variants of SLC6A4, HTR1A, HTR2A or TPH1 are associated with suicide attempts in BN individuals.

Type
Poster Session I: Eating Disorders
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S181
Copyright
Copyright © European Psychiatric Association 2008
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