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P03-27 - Drug use and Age at Onset of Psychosis

Published online by Cambridge University Press:  17 April 2020

M.L. Barrigon ,
M. Ruiz-Veguilla ,
M. Ferrin ,
J.M. Moreno ,
M.D. Salcedo ,
F.J. Diaz ,
J. Cervilla  and
M. Gurpegui
M.L. Barrigon
Affiliation:
Psychiatry Service, Santa Ana Hospital, Motril Developmental Neuropsychiatry Research Unit, Jaén Medical Center, Jaén, Spain
M. Ruiz-Veguilla
Affiliation:
Developmental Neuropsychiatry Research Unit, Jaén Medical Center, Jaén, Spain
M. Ferrin
Affiliation:
Developmental Neuropsychiatry Research Unit, Jaén Medical Center, Jaén, Spain Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J.M. Moreno
Affiliation:
Developmental Neuropsychiatry Research Unit, Jaén Medical Center, Jaén, Spain
M.D. Salcedo
Affiliation:
Developmental Neuropsychiatry Research Unit, Jaén Medical Center, Jaén, Spain
F.J. Diaz
Affiliation:
Department of Biostatistics, The University of Kansas Medical Center, Kansas City, KS, USA
J. Cervilla
Affiliation:
Psychiatry Department, University of Granada, Granada, Spain
M. Gurpegui
Affiliation:
Psychiatry Department, University of Granada, Granada, Spain

Abstract

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Objective

We analyzed the association of age at onset of psychosis(AOP) with having a history of cannabis use in patients with a first episode of non-affective psychosis(FENAP) and investigated the impact on the AOP of exposure to cannabis in adolescence, compared with young adulthood, and of the additional exposure to cocaine.

Method

We recruited 112 consecutive patients with a FENAP. CIDI was used to assess drug use and to define the age at onset of heaviest use(AOHU) of a drug, as the age when drug was used the most for each patient. The effect of cannabis and cocaine AOHU on AOP was explored through Kruskal-Wallis and Mann-Whitney tests, and logistic regression. Sex-adjusted cumulative hazard curves and Cox regression models were used to compare the AOP of patients with and without a history of cannabis use, or associated cocaine use.

Results

AOP was significantly associated with the use of cannabis, independently of sex, use of cocaine, tobacco smoking or excessive alcohol consumption. There was a dose-response relationship between cannabis AOHU and AOP: the earlier the AOHU the earlier the AOP. Hazard curves showed that patients with a history of cannabis use had a higher hazard of having a first episode psychosis than the rest of the patients (sex-adjusted log rank χ2=23.43,df=1, p< 0.001). Their respective median AOP (25th, 75th percentiles) were 23.5 (21,28) and 33.5 years (27,45) (for log-transformed AOP, t=5.6, df=110, p< 0.001).

Conclusions

Our results are in favor of a catalytic role for cannabis use in onset of psychosis.

Type
Psychotic disorders / Schizophrenia
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E1137
Copyright
Copyright © European Psychiatric Association 2010
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