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P0266 - Metabolic side effects of atypical antipsychotics in early onset schizophrenia: One year follow-up pilot study

Published online by Cambridge University Press:  16 April 2020

J.L. Goeb ,
S. Marco ,
A. Duhamel ,
R. Jardri ,
G. Kechid ,
R. Bordet ,
P. Delion  and
P. Thomas
J.L. Goeb
Affiliation:
Department of Child and Adolescent Psychiatry, University Hospital Centre of Lille, Lille, France
S. Marco
Affiliation:
Department of Child and Adolescent Psychiatry, University Hospital Centre of Lille, Lille, France
A. Duhamel
Affiliation:
Department of Biostatistics, CERIM, University of Lille, Lille, France
R. Jardri
Affiliation:
Department of Child and Adolescent Psychiatry, University Hospital Centre of Lille, Lille, France
G. Kechid
Affiliation:
Department of Child and Adolescent Psychiatry, University Hospital Centre of Lille, Lille, France
R. Bordet
Affiliation:
Department of Pharmacology, University of Lille, Lille, France
P. Delion
Affiliation:
Department of Child and Adolescent Psychiatry, University Hospital Centre of Lille, Lille, France
P. Thomas
Affiliation:
Department of General Psychiatry, University Hospital Centre, Lille, France

Abstract

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Objective:

To assess weight gain in adolescents treated with antipsychotic drugs for early onset schizophrenia (EOS).

Method:

One-year follow-up of 13 consecutive adolescents (10 male, 3 females, age range: 11-16) treated with atypical antipsychotics for early onset schizophrenia (according to DSM-IV criterias). The main outcome measure is sex- and age-adjusted Z scores of Body Mass Index (BMI).

Results:

BMI, sex- and age-adjusted BMI percentiles and BMI Z scores are significantly increased in schizophrenic adolescents after prescription of atypical antipsychotics (p= 0.025).

Conclusions:

Despite the limited number of children included, this pilot study confirms a significant link between prescription of risperidone in early onset schizophrenia and increase of adjusted BMIZ scores. Clinicians and caregivers are to be aware of potential metabolic adverse effects of these medications. These findings suggest a regular health monitoring in adolescents treated with atypical antipsychotics, before and along the prescription.

Type
Poster Session I: Neuroleptics and Antipsychotics
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S159
Copyright
Copyright © European Psychiatric Association 2008
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